Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors

Protein kinase PKR is activated during viral infection and phosphorylates the α subunit of eukaryotic translation initiation factor 2 (eIF2), leading to inhibition of translation and viral replication. We report fast evolution of the PKR kinase domain in vertebrates, coupled with positive selection...

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Detalles Bibliográficos
Autores principales: Rothenburg, Stefan, Seo, Eun Joo, Gibbs, James S., Dever, Thomas E., Dittmar, Katharina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142916/
https://www.ncbi.nlm.nih.gov/pubmed/19043413
http://dx.doi.org/10.1038/nsmb.1529

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142916/
https://www.ncbi.nlm.nih.gov/pubmed/19043413
http://dx.doi.org/10.1038/nsmb.1529

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