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Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors

Protein kinase PKR is activated during viral infection and phosphorylates the α subunit of eukaryotic translation initiation factor 2 (eIF2), leading to inhibition of translation and viral replication. We report fast evolution of the PKR kinase domain in vertebrates, coupled with positive selection...

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Detalles Bibliográficos
Autores principales:	Rothenburg, Stefan, Seo, Eun Joo, Gibbs, James S., Dever, Thomas E., Dittmar, Katharina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2008
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142916/ https://www.ncbi.nlm.nih.gov/pubmed/19043413 http://dx.doi.org/10.1038/nsmb.1529

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