Separase Loss of Function Cooperates with the Loss of p53 in the Initiation and Progression of T- and B-Cell Lymphoma, Leukemia and Aneuploidy in Mice

BACKGROUND: Cohesin protease Separase plays a key role in faithful segregation of sister chromatids by cleaving the cohesin complex at the metaphase to anaphase transition. Homozygous deletion of ESPL1 gene that encodes Separase protein results in embryonic lethality in mice and Separase overexpress...

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Detalles Bibliográficos
Autores principales: Mukherjee, Malini, Ge, Gouqing, Zhang, Nenggang, Huang, Eryong, Nakamura, Lanelle V., Minor, Marissa, Fofanov, Viacheslav, Rao, Pullivarthi H., Herron, Alan, Pati, Debananda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143119/
https://www.ncbi.nlm.nih.gov/pubmed/21799785
http://dx.doi.org/10.1371/journal.pone.0022167

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