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New Insights in the Removal of the Hydantoins, Oxidation Product of Pyrimidines, via the Base Excision and Nucleotide Incision Repair Pathways

BACKGROUND: Oxidative damage to DNA, if not repaired, can be both miscoding and blocking. These genetic alterations can lead to mutations and/or cell death, which in turn cause cancer and aging. Oxidized DNA bases are substrates for two overlapping repair pathways: base excision (BER) and nucleotide...

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Detalles Bibliográficos
Autores principales:	Redrejo-Rodríguez, Modesto, Saint-Pierre, Christine, Couve, Sophie, Mazouzi, Abdelghani, Ishchenko, Alexander A., Gasparutto, Didier, Saparbaev, Murat
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143120/ https://www.ncbi.nlm.nih.gov/pubmed/21799731 http://dx.doi.org/10.1371/journal.pone.0021039

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