Ubiquitin Ligase RNF146 Regulates Tankyrase and Axin to Promote Wnt Signaling

Canonical Wnt signaling is controlled intracellularly by the level of β-catenin protein, which is dependent on Axin scaffolding of a complex that phosphorylates β-catenin to target it for ubiquitylation and proteasomal degradation. This function of Axin is counteracted through relocalization of Axin...

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Detalles Bibliográficos
Autores principales: Callow, Marinella G., Tran, Hoanh, Phu, Lilian, Lau, Ted, Lee, James, Sandoval, Wendy N., Liu, Peter S., Bheddah, Sheila, Tao, Janet, Lill, Jennie R., Hongo, Jo-Anne, Davis, David, Kirkpatrick, Donald S., Polakis, Paul, Costa, Mike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143158/
https://www.ncbi.nlm.nih.gov/pubmed/21799911
http://dx.doi.org/10.1371/journal.pone.0022595

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