The UNC-45 Chaperone Is Critical for Establishing Myosin-Based Myofibrillar Organization and Cardiac Contractility in the Drosophila Heart Model

UNC-45 is a UCS (UNC-45/CRO1/She4P) class chaperone necessary for myosin folding and/or accumulation, but its requirement for maintaining cardiac contractility has not been explored. Given the prevalence of myosin mutations in eliciting cardiomyopathy, chaperones like UNC-45 are likely to be equally...

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Detalles Bibliográficos
Autores principales: Melkani, Girish C., Bodmer, Rolf, Ocorr, Karen, Bernstein, Sanford I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143160/
https://www.ncbi.nlm.nih.gov/pubmed/21799905
http://dx.doi.org/10.1371/journal.pone.0022579

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