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Eeyarestatin 1 Interferes with Both Retrograde and Anterograde Intracellular Trafficking Pathways

BACKGROUND: The small molecule Eeyarestatin I (ESI) inhibits the endoplasmic reticulum (ER)-cytosol dislocation and subsequent degradation of ERAD (ER associated protein degradation) substrates. Toxins such as ricin and Shiga/Shiga-like toxins (SLTx) are endocytosed and trafficked to the ER. Their c...

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Detalles Bibliográficos
Autores principales:	Aletrari, Mina-Olga, McKibbin, Craig, Williams, Helen, Pawar, Vidya, Pietroni, Paola, Lord, J. Michael, Flitsch, Sabine L., Whitehead, Roger, Swanton, Eileithyia, High, Stephen, Spooner, Robert A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143184/ https://www.ncbi.nlm.nih.gov/pubmed/21799938 http://dx.doi.org/10.1371/journal.pone.0022713

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