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Detoxification: A Novel Function of BRCA1 in Tumor Suppression?

Our studies found that BRCA1 levels negatively correlate with DNA adducts induced by Benzo(a)pyrene (BaP). Pulse-chase experiments showed that the increase in BaP-induced DNA adducts in BRCA1 knockdown cells may not be associated with BRCA1’s function in nucleotide excision repair activity; rather,...

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Detalles Bibliográficos
Autores principales:	Kang, Hyo Jin, Hong, Young Bin, Kim, Hee Jeong, Rodriguez, Olga C., Nath, Raghu G., Tilli, Elena M., Albanese, Christopher, Chung, Fung-Lung, Kwon, Sang Hoon, Bae, Insoo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2011
Materias:	Carcinogenicity
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143468/ https://www.ncbi.nlm.nih.gov/pubmed/21507987 http://dx.doi.org/10.1093/toxsci/kfr089

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