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Virtual screening, identification and experimental testing of novel inhibitors of PBEF1/Visfatin/NMPRTase for glioma therapy
BACKGROUND: Pre-B-cell colony enhancing factor 1 gene (PBEF1) encodes nicotinamide phosphoribosyltransferase (NMPRTase), which catalyses the rate limiting step in the salvage pathway of NAD(+ )metabolism in mammalian cells. PBEF1 transcript and protein levels have been shown to be elevated in gliobl...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143896/ https://www.ncbi.nlm.nih.gov/pubmed/21884623 http://dx.doi.org/10.1186/2043-9113-1-5 |