Virtual screening, identification and experimental testing of novel inhibitors of PBEF1/Visfatin/NMPRTase for glioma therapy

BACKGROUND: Pre-B-cell colony enhancing factor 1 gene (PBEF1) encodes nicotinamide phosphoribosyltransferase (NMPRTase), which catalyses the rate limiting step in the salvage pathway of NAD(+ )metabolism in mammalian cells. PBEF1 transcript and protein levels have been shown to be elevated in gliobl...

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Detalles Bibliográficos
Autores principales: Chandra, Nagasuma, Bhagavat, Raghu, Sharma, Eshita, Sreekanthreddy, P, Somasundaram, Kumaravel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143896/
https://www.ncbi.nlm.nih.gov/pubmed/21884623
http://dx.doi.org/10.1186/2043-9113-1-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143896/
https://www.ncbi.nlm.nih.gov/pubmed/21884623
http://dx.doi.org/10.1186/2043-9113-1-5

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