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Association studies for asthma and atopic diseases: a comprehensive review of the literature

Hundreds of genetic association studies on asthma-related phenotypes have been conducted in different populations. To date, variants in 64 genes have been reported to be associated with asthma or related traits in at least one study. Of these, 33 associations were replicated in a second study, 9 ass...

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Detalles Bibliográficos
Autores principales: Hoffjan, Sabine, Nicolae, Dan, Ober, Carole
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC314398/
https://www.ncbi.nlm.nih.gov/pubmed/14748924
http://dx.doi.org/10.1186/1465-9921-4-14
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author Hoffjan, Sabine
Nicolae, Dan
Ober, Carole
author_facet Hoffjan, Sabine
Nicolae, Dan
Ober, Carole
author_sort Hoffjan, Sabine
collection PubMed
description Hundreds of genetic association studies on asthma-related phenotypes have been conducted in different populations. To date, variants in 64 genes have been reported to be associated with asthma or related traits in at least one study. Of these, 33 associations were replicated in a second study, 9 associations were not replicated either in a second study or a second sample in the same study, and 22 associations were reported in just a single published study. These results suggest the potential for a great amount of heterogeneity underlying asthma. However, many of these studies are methodologically limited and their interpretation hampered by small sample sizes.
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spelling pubmed-3143982004-01-17 Association studies for asthma and atopic diseases: a comprehensive review of the literature Hoffjan, Sabine Nicolae, Dan Ober, Carole Respir Res Review Hundreds of genetic association studies on asthma-related phenotypes have been conducted in different populations. To date, variants in 64 genes have been reported to be associated with asthma or related traits in at least one study. Of these, 33 associations were replicated in a second study, 9 associations were not replicated either in a second study or a second sample in the same study, and 22 associations were reported in just a single published study. These results suggest the potential for a great amount of heterogeneity underlying asthma. However, many of these studies are methodologically limited and their interpretation hampered by small sample sizes. BioMed Central 2003 2003-12-04 /pmc/articles/PMC314398/ /pubmed/14748924 http://dx.doi.org/10.1186/1465-9921-4-14 Text en Copyright © 2003 Hoffjan et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
spellingShingle Review
Hoffjan, Sabine
Nicolae, Dan
Ober, Carole
Association studies for asthma and atopic diseases: a comprehensive review of the literature
title Association studies for asthma and atopic diseases: a comprehensive review of the literature
title_full Association studies for asthma and atopic diseases: a comprehensive review of the literature
title_fullStr Association studies for asthma and atopic diseases: a comprehensive review of the literature
title_full_unstemmed Association studies for asthma and atopic diseases: a comprehensive review of the literature
title_short Association studies for asthma and atopic diseases: a comprehensive review of the literature
title_sort association studies for asthma and atopic diseases: a comprehensive review of the literature
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC314398/
https://www.ncbi.nlm.nih.gov/pubmed/14748924
http://dx.doi.org/10.1186/1465-9921-4-14
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