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Association studies for asthma and atopic diseases: a comprehensive review of the literature
Hundreds of genetic association studies on asthma-related phenotypes have been conducted in different populations. To date, variants in 64 genes have been reported to be associated with asthma or related traits in at least one study. Of these, 33 associations were replicated in a second study, 9 ass...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2003
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC314398/ https://www.ncbi.nlm.nih.gov/pubmed/14748924 http://dx.doi.org/10.1186/1465-9921-4-14 |
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author | Hoffjan, Sabine Nicolae, Dan Ober, Carole |
author_facet | Hoffjan, Sabine Nicolae, Dan Ober, Carole |
author_sort | Hoffjan, Sabine |
collection | PubMed |
description | Hundreds of genetic association studies on asthma-related phenotypes have been conducted in different populations. To date, variants in 64 genes have been reported to be associated with asthma or related traits in at least one study. Of these, 33 associations were replicated in a second study, 9 associations were not replicated either in a second study or a second sample in the same study, and 22 associations were reported in just a single published study. These results suggest the potential for a great amount of heterogeneity underlying asthma. However, many of these studies are methodologically limited and their interpretation hampered by small sample sizes. |
format | Text |
id | pubmed-314398 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2003 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-3143982004-01-17 Association studies for asthma and atopic diseases: a comprehensive review of the literature Hoffjan, Sabine Nicolae, Dan Ober, Carole Respir Res Review Hundreds of genetic association studies on asthma-related phenotypes have been conducted in different populations. To date, variants in 64 genes have been reported to be associated with asthma or related traits in at least one study. Of these, 33 associations were replicated in a second study, 9 associations were not replicated either in a second study or a second sample in the same study, and 22 associations were reported in just a single published study. These results suggest the potential for a great amount of heterogeneity underlying asthma. However, many of these studies are methodologically limited and their interpretation hampered by small sample sizes. BioMed Central 2003 2003-12-04 /pmc/articles/PMC314398/ /pubmed/14748924 http://dx.doi.org/10.1186/1465-9921-4-14 Text en Copyright © 2003 Hoffjan et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. |
spellingShingle | Review Hoffjan, Sabine Nicolae, Dan Ober, Carole Association studies for asthma and atopic diseases: a comprehensive review of the literature |
title | Association studies for asthma and atopic diseases: a comprehensive review of the literature |
title_full | Association studies for asthma and atopic diseases: a comprehensive review of the literature |
title_fullStr | Association studies for asthma and atopic diseases: a comprehensive review of the literature |
title_full_unstemmed | Association studies for asthma and atopic diseases: a comprehensive review of the literature |
title_short | Association studies for asthma and atopic diseases: a comprehensive review of the literature |
title_sort | association studies for asthma and atopic diseases: a comprehensive review of the literature |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC314398/ https://www.ncbi.nlm.nih.gov/pubmed/14748924 http://dx.doi.org/10.1186/1465-9921-4-14 |
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