Cargando…
The diagnosis and management of pre-invasive breast disease: Promise of new technologies in understanding pre-invasive breast lesions
Array-based comparative genomic hybridization, RNA expression profiling, and proteomic analyses are new molecular technologies used to study breast cancer. Invasive breast cancers were originally evaluated because they provided ample quantities of DNA, RNA, and protein. The application of these tech...
Autores principales: | , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2003
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC314415/ https://www.ncbi.nlm.nih.gov/pubmed/14580250 |
_version_ | 1782121114810449920 |
---|---|
author | Jeffrey, Stefanie S Pollack, Jonathan R |
author_facet | Jeffrey, Stefanie S Pollack, Jonathan R |
author_sort | Jeffrey, Stefanie S |
collection | PubMed |
description | Array-based comparative genomic hybridization, RNA expression profiling, and proteomic analyses are new molecular technologies used to study breast cancer. Invasive breast cancers were originally evaluated because they provided ample quantities of DNA, RNA, and protein. The application of these technologies to pre-invasive breast lesions is discussed, including methods that facilitate their implementation. Data indicate that atypical ductal hyperplasia and ductal carcinoma in situ are precursor lesions molecularly similar to adjacent invasive breast cancer. It is expected that molecular technologies will identify breast tissue at risk for the development of unfavorable subtypes of invasive breast cancer and reveal strategies for targeted chemoprevention or eradication. |
format | Text |
id | pubmed-314415 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2003 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-3144152004-01-17 The diagnosis and management of pre-invasive breast disease: Promise of new technologies in understanding pre-invasive breast lesions Jeffrey, Stefanie S Pollack, Jonathan R Breast Cancer Res Review Array-based comparative genomic hybridization, RNA expression profiling, and proteomic analyses are new molecular technologies used to study breast cancer. Invasive breast cancers were originally evaluated because they provided ample quantities of DNA, RNA, and protein. The application of these technologies to pre-invasive breast lesions is discussed, including methods that facilitate their implementation. Data indicate that atypical ductal hyperplasia and ductal carcinoma in situ are precursor lesions molecularly similar to adjacent invasive breast cancer. It is expected that molecular technologies will identify breast tissue at risk for the development of unfavorable subtypes of invasive breast cancer and reveal strategies for targeted chemoprevention or eradication. BioMed Central 2003 2003-10-09 /pmc/articles/PMC314415/ /pubmed/14580250 Text en Copyright © 2003 BioMed Central Ltd |
spellingShingle | Review Jeffrey, Stefanie S Pollack, Jonathan R The diagnosis and management of pre-invasive breast disease: Promise of new technologies in understanding pre-invasive breast lesions |
title | The diagnosis and management of pre-invasive breast disease: Promise of new technologies in understanding pre-invasive breast lesions |
title_full | The diagnosis and management of pre-invasive breast disease: Promise of new technologies in understanding pre-invasive breast lesions |
title_fullStr | The diagnosis and management of pre-invasive breast disease: Promise of new technologies in understanding pre-invasive breast lesions |
title_full_unstemmed | The diagnosis and management of pre-invasive breast disease: Promise of new technologies in understanding pre-invasive breast lesions |
title_short | The diagnosis and management of pre-invasive breast disease: Promise of new technologies in understanding pre-invasive breast lesions |
title_sort | diagnosis and management of pre-invasive breast disease: promise of new technologies in understanding pre-invasive breast lesions |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC314415/ https://www.ncbi.nlm.nih.gov/pubmed/14580250 |
work_keys_str_mv | AT jeffreystefanies thediagnosisandmanagementofpreinvasivebreastdiseasepromiseofnewtechnologiesinunderstandingpreinvasivebreastlesions AT pollackjonathanr thediagnosisandmanagementofpreinvasivebreastdiseasepromiseofnewtechnologiesinunderstandingpreinvasivebreastlesions AT jeffreystefanies diagnosisandmanagementofpreinvasivebreastdiseasepromiseofnewtechnologiesinunderstandingpreinvasivebreastlesions AT pollackjonathanr diagnosisandmanagementofpreinvasivebreastdiseasepromiseofnewtechnologiesinunderstandingpreinvasivebreastlesions |