Cargando…

Nuclear translocation of AMPK-α1 potentiates striatal neurodegeneration in Huntington’s disease

Adenosine monophosphate–activated protein kinase (AMPK) is a major energy sensor that maintains cellular energy homeostasis. Huntington’s disease (HD) is a neurodegenerative disorder caused by the expansion of CAG repeats in the huntingtin (Htt) gene. In this paper, we report that activation of the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ju, Tz-Chuen, Chen, Hui-Mei, Lin, Jiun-Tsai, Chang, Ching-Pang, Chang, Wei-Cheng, Kang, Jheng-Jie, Sun, Cheng-Pu, Tao, Mi-Hua, Tu, Pang-Hsien, Chang, Chen, Dickson, Dennis W., Chern, Yijuang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2011
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144412/ https://www.ncbi.nlm.nih.gov/pubmed/21768291 http://dx.doi.org/10.1083/jcb.201105010

Ejemplares similares

Insights into GABA(A)ergic system alteration in Huntington's disease
por: Hsu, Yi-Ting, et al.
Publicado: (2018)

Proteostasis in striatal cells and selective neurodegeneration in Huntington’s disease
por: Margulis, Julia, et al.
Publicado: (2014)

Striatal Neurodegeneration that Mimics Huntington’s Disease Modifies GABA-induced Currents
por: Flores-Hernández, Jorge, et al.
Publicado: (2018)

Targeting the equilibrative nucleoside transporter ENT1 in Huntington disease
por: Guitart, Xavier, et al.
Publicado: (2017)

High Protein Diet and Huntington's Disease
por: Chen, Chiung-Mei, et al.
Publicado: (2015)

A Role for Oxidized DNA Precursors in Huntington's Disease–Like Striatal Neurodegeneration
por: De Luca, Gabriele, et al.
Publicado: (2008)

Emerging roles of dysregulated adenosine homeostasis in brain disorders with a specific focus on neurodegenerative diseases
por: Chang, Ching-Pang, et al.
Publicado: (2021)

Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington’s disease
por: Siew, Jian Jing, et al.
Publicado: (2019)

Type VI adenylyl cyclase negatively regulates GluN2B-mediated LTD and spatial reversal learning
por: Chang, Ching-Pang, et al.
Publicado: (2016)

Huntington’s Disease and Striatal Signaling
por: Roze, Emmanuel, et al.
Publicado: (2011)

A New Drug Design Targeting the Adenosinergic System for Huntington's Disease
por: Huang, Nai-Kuei, et al.
Publicado: (2011)

Human Mesenchymal Stem Cells Prolong Survival and Ameliorate Motor Deficit through Trophic Support in Huntington's Disease Mouse Models
por: Lin, Yuan-Ta, et al.
Publicado: (2011)

Besides Huntington's disease, does brain-type creatine kinase play a role in other forms of hearing impairment resulting from a common pathological cause?
por: Lin, Yow-Sien, et al.
Publicado: (2011)

Cortical and Striatal Circuits in Huntington’s Disease
por: Blumenstock, Sonja, et al.
Publicado: (2020)

Striatal network modeling in Huntington’s Disease
por: Ponzi, Adam, et al.
Publicado: (2020)

Functional roles of ST8SIA3-mediated sialylation of striatal dopamine D(2) and adenosine A(2A) receptors
por: Lin, Chien-Yu, et al.
Publicado: (2019)

AMPK amplifies Huntington's disease
por: Short, Ben
Publicado: (2011)

Ginsenoside compound K reduces the progression of Huntington's disease via the inhibition of oxidative stress and overactivation of the ATM/AMPK pathway
por: Hua, Kuo-Feng, et al.
Publicado: (2022)

A selective inhibitor of the NLRP3 inflammasome as a potential therapeutic approach for neuroprotection in a transgenic mouse model of Huntington’s disease
por: Chen, Kai-Po, et al.
Publicado: (2022)

Striatal Interneurons in Transgenic Nonhuman Primate Model of Huntington’s Disease
por: Lallani, Shoeb B., et al.
Publicado: (2019)

The Impact of Dysregulated microRNA Biogenesis Machinery and microRNA Sorting on Neurodegenerative Diseases
por: Weng, Yu-Ting, et al.
Publicado: (2023)

The mechanism of degeneration of striatal neuronal subtypes in Huntington disease
por: Rikani, Azadeh A., et al.
Publicado: (2014)

Striatal Vulnerability in Huntington’s Disease: Neuroprotection Versus Neurotoxicity
por: Morigaki, Ryoma, et al.
Publicado: (2017)

Striatal Network Models of Huntington's Disease Dysfunction Phenotypes
por: Zheng, Pengsheng, et al.
Publicado: (2017)

Early Changes in Striatal Activity and Motor Kinematics in a Huntington's Disease Mouse Model
por: Koch, Ellen T., et al.
Publicado: (2022)

Nanoscopic Insights of Amphiphilic Peptide against the Oligomer Assembly Process to Treat Huntington's Disease
por: He, Ruei‐Yu, et al.
Publicado: (2019)

Striatal parvalbuminergic neurons are lost in Huntington's disease: implications for dystonia
por: Reiner, Anton, et al.
Publicado: (2013)

Dual tasking impairments are associated with striatal pathology in Huntington’s disease
por: Lo, Johnny, et al.
Publicado: (2020)

Glycation potentiates neurodegeneration in models of Huntington’s disease
por: Vicente Miranda, Hugo, et al.
Publicado: (2016)

Neurovascular abnormalities in brain disorders: highlights with angiogenesis and magnetic resonance imaging studies
por: Chen, Chiao-Chi V, et al.
Publicado: (2013)

AMPK/AS160 mediates tiliroside derivatives-stimulated GLUT4 translocation in muscle cells
por: Zhang, Chang, et al.
Publicado: (2018)

Gene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington’s disease
por: Wu, Zheng, et al.
Publicado: (2020)

Energy Homeostasis and Abnormal RNA Metabolism in Amyotrophic Lateral Sclerosis
por: Liu, Yu-Ju, et al.
Publicado: (2017)

Fetal striatal grafting slows motor and cognitive decline of Huntington's disease
por: Paganini, Marco, et al.
Publicado: (2014)

VGF and striatal cell damage in in vitro and in vivo models of Huntington’s disease
por: Noda, Yasuhiro, et al.
Publicado: (2015)

Preserving cortico-striatal function: deep brain stimulation in Huntington’s disease
por: Nagel, Sean J., et al.
Publicado: (2015)

Functional connectivity modeling of consistent cortico-striatal degeneration in Huntington's disease
por: Dogan, Imis, et al.
Publicado: (2015)

Altered enhancer transcription underlies Huntington’s disease striatal transcriptional signature
por: Le Gras, Stéphanie, et al.
Publicado: (2017)

Rate of torque development and striatal shape in individuals with prodromal Huntington's disease
por: Cruickshank, Travis, et al.
Publicado: (2020)

Diminished LC3-Associated Phagocytosis by Huntington’s Disease Striatal Astrocytes
por: Wakida, Nicole M., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_fcr5ulhsgbqmr7jt0ujioegq8g