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Coexistence of HER2 over-expression and p53 protein accumulation is a strong prognostic molecular marker in breast cancer

INTRODUCTION: Many laboratories are currently evaluating the usefulness of determination of HER2, p53, and Ki67 proliferation indices using immunohistochemical techniques in cancer. Although the available studies suggest that these factors might indeed be helpful in making treatment decisions in can...

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Autores principales: Yamashita, Hiroko, Nishio, Mariko, Toyama, Tatsuya, Sugiura, Hiroshi, Zhang, Zhenhuan, Kobayashi, Shunzo, Iwase, Hirotaka
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC314452/
https://www.ncbi.nlm.nih.gov/pubmed/14680497
http://dx.doi.org/10.1186/bcr738
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author Yamashita, Hiroko
Nishio, Mariko
Toyama, Tatsuya
Sugiura, Hiroshi
Zhang, Zhenhuan
Kobayashi, Shunzo
Iwase, Hirotaka
author_facet Yamashita, Hiroko
Nishio, Mariko
Toyama, Tatsuya
Sugiura, Hiroshi
Zhang, Zhenhuan
Kobayashi, Shunzo
Iwase, Hirotaka
author_sort Yamashita, Hiroko
collection PubMed
description INTRODUCTION: Many laboratories are currently evaluating the usefulness of determination of HER2, p53, and Ki67 proliferation indices using immunohistochemical techniques in cancer. Although the available studies suggest that these factors might indeed be helpful in making treatment decisions in cancer patients, their clinical usefulness is still controversial. METHODS: Expression of HER2, p53, and Ki67 was examined by immunohistochemistry in samples of breast tissue from 506 patients with invasive ductal carcinoma, obtained between 1981 and 1999 (median follow up period 82 months), and their significance for prognosis was analyzed. RESULTS: Of the 506 carcinoma tissue samples, 20.1%, 29.0%, and 53.6% were positive for HER2 over-expression, p53 protein accumulation, and Ki67 expression, respectively. Over-expression of HER2 significantly reduced disease free (P = 0.02) and overall survival (P = 0.005). Accumulation of p53 protein significantly decreased disease free (P = 0.01) and overall survival (P = 0.01). Patients with tumors that were positive for both HER2 and p53 relapsed and died within a significantly shorter period of time after surgery (P = 0.0001 and P < 0.0001, respectively). In multivariate analysis, patients with both HER2 and p53 positive tumors had considerably decreased overall survival (P = 0.04), as did patients with larger tumor size and positive lymph node status. CONCLUSION: The findings of the present study indicate that the coexistence of HER2 over-expression and p53 protein accumulation is a strong prognostic molecular marker in breast cancer.
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spelling pubmed-3144522004-01-17 Coexistence of HER2 over-expression and p53 protein accumulation is a strong prognostic molecular marker in breast cancer Yamashita, Hiroko Nishio, Mariko Toyama, Tatsuya Sugiura, Hiroshi Zhang, Zhenhuan Kobayashi, Shunzo Iwase, Hirotaka Breast Cancer Res Research Article INTRODUCTION: Many laboratories are currently evaluating the usefulness of determination of HER2, p53, and Ki67 proliferation indices using immunohistochemical techniques in cancer. Although the available studies suggest that these factors might indeed be helpful in making treatment decisions in cancer patients, their clinical usefulness is still controversial. METHODS: Expression of HER2, p53, and Ki67 was examined by immunohistochemistry in samples of breast tissue from 506 patients with invasive ductal carcinoma, obtained between 1981 and 1999 (median follow up period 82 months), and their significance for prognosis was analyzed. RESULTS: Of the 506 carcinoma tissue samples, 20.1%, 29.0%, and 53.6% were positive for HER2 over-expression, p53 protein accumulation, and Ki67 expression, respectively. Over-expression of HER2 significantly reduced disease free (P = 0.02) and overall survival (P = 0.005). Accumulation of p53 protein significantly decreased disease free (P = 0.01) and overall survival (P = 0.01). Patients with tumors that were positive for both HER2 and p53 relapsed and died within a significantly shorter period of time after surgery (P = 0.0001 and P < 0.0001, respectively). In multivariate analysis, patients with both HER2 and p53 positive tumors had considerably decreased overall survival (P = 0.04), as did patients with larger tumor size and positive lymph node status. CONCLUSION: The findings of the present study indicate that the coexistence of HER2 over-expression and p53 protein accumulation is a strong prognostic molecular marker in breast cancer. BioMed Central 2004 2003-11-07 /pmc/articles/PMC314452/ /pubmed/14680497 http://dx.doi.org/10.1186/bcr738 Text en Copyright © 2004 Yamashita et al., licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
spellingShingle Research Article
Yamashita, Hiroko
Nishio, Mariko
Toyama, Tatsuya
Sugiura, Hiroshi
Zhang, Zhenhuan
Kobayashi, Shunzo
Iwase, Hirotaka
Coexistence of HER2 over-expression and p53 protein accumulation is a strong prognostic molecular marker in breast cancer
title Coexistence of HER2 over-expression and p53 protein accumulation is a strong prognostic molecular marker in breast cancer
title_full Coexistence of HER2 over-expression and p53 protein accumulation is a strong prognostic molecular marker in breast cancer
title_fullStr Coexistence of HER2 over-expression and p53 protein accumulation is a strong prognostic molecular marker in breast cancer
title_full_unstemmed Coexistence of HER2 over-expression and p53 protein accumulation is a strong prognostic molecular marker in breast cancer
title_short Coexistence of HER2 over-expression and p53 protein accumulation is a strong prognostic molecular marker in breast cancer
title_sort coexistence of her2 over-expression and p53 protein accumulation is a strong prognostic molecular marker in breast cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC314452/
https://www.ncbi.nlm.nih.gov/pubmed/14680497
http://dx.doi.org/10.1186/bcr738
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