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Calcium modulates force sensing by the von Willebrand factor A2 domain

von Willebrand factor (VWF) multimers mediate primary adhesion and aggregation of platelets. VWF potency critically depends on multimer size, which is regulated by a feedback mechanism involving shear-induced unfolding of the VWF-A2 domain and cleavage by the metalloprotease ADAMTS-13. Here we repor...

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Detalles Bibliográficos
Autores principales:	Jakobi, Arjen J., Mashaghi, Alireza, Tans, Sander J., Huizinga, Eric G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144584/ https://www.ncbi.nlm.nih.gov/pubmed/21750539 http://dx.doi.org/10.1038/ncomms1385

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