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Evaluation of the autologous bone marrow mononuclear therapy and functional restoration in the scarred myocardium by imaging analysis
A 62-year-old male patient with previous history of myocardial infarction, akinetic myocardial segments, and an ejection fraction of 31% with the NYHA class III category was selected for the autologous bone marrow (ABM)-derived mononuclear cell fraction injection during CABG surgery. Nitrate augment...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications Pvt Ltd
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144623/ https://www.ncbi.nlm.nih.gov/pubmed/21814420 http://dx.doi.org/10.4103/0975-3583.83037 |
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author | Gokhale, Alla Gopala Krishna Chelluri, Lakshmi Kiran Kumaresan, K. Subramanyam, G. Sudhakar, K. Vemuri, Sathish Debnath, Tanya Ratnakar, K. S. |
author_facet | Gokhale, Alla Gopala Krishna Chelluri, Lakshmi Kiran Kumaresan, K. Subramanyam, G. Sudhakar, K. Vemuri, Sathish Debnath, Tanya Ratnakar, K. S. |
author_sort | Gokhale, Alla Gopala Krishna |
collection | PubMed |
description | A 62-year-old male patient with previous history of myocardial infarction, akinetic myocardial segments, and an ejection fraction of 31% with the NYHA class III category was selected for the autologous bone marrow (ABM)-derived mononuclear cell fraction injection during CABG surgery. Nitrate augmented myocardial tracer uptake was imaged by ECG gated SPECT pre- and 1 year post-ABM therapy, using radiotracer Tc99m Sestamibi. The baseline gated SPECT demonstrated full thickness infarct in 40% area of LAD territory. Bone marrow aspirate of 20.0 ml from sternum yielding a mono nuclear cell fraction of 4.5 × 10(7) cells/ml was suspended in 2.0 ml of sterile normal saline to be injected at eight sites of the injured myocardium. There were no apparent side effects due to the procedure, i.e., life threatening events, major bleeds, reaction, or shock. The case was followed at the end of 1, 3, 6 months by ECG and Holter monitor and ECG gated SPECT at the end of 12 months. The gated SPECT images demonstrated mild but definitely improved tracer uptake within part of the infarcted segments along with improvement in ejection fraction to 45%, and a clinical change in the NYHA Class to II. Cell-based therapy may offer benefits of induction of normal tissue microenvironment. |
format | Online Article Text |
id | pubmed-3144623 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Medknow Publications Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-31446232011-08-03 Evaluation of the autologous bone marrow mononuclear therapy and functional restoration in the scarred myocardium by imaging analysis Gokhale, Alla Gopala Krishna Chelluri, Lakshmi Kiran Kumaresan, K. Subramanyam, G. Sudhakar, K. Vemuri, Sathish Debnath, Tanya Ratnakar, K. S. J Cardiovasc Dis Res Clinical Case Report Based Study A 62-year-old male patient with previous history of myocardial infarction, akinetic myocardial segments, and an ejection fraction of 31% with the NYHA class III category was selected for the autologous bone marrow (ABM)-derived mononuclear cell fraction injection during CABG surgery. Nitrate augmented myocardial tracer uptake was imaged by ECG gated SPECT pre- and 1 year post-ABM therapy, using radiotracer Tc99m Sestamibi. The baseline gated SPECT demonstrated full thickness infarct in 40% area of LAD territory. Bone marrow aspirate of 20.0 ml from sternum yielding a mono nuclear cell fraction of 4.5 × 10(7) cells/ml was suspended in 2.0 ml of sterile normal saline to be injected at eight sites of the injured myocardium. There were no apparent side effects due to the procedure, i.e., life threatening events, major bleeds, reaction, or shock. The case was followed at the end of 1, 3, 6 months by ECG and Holter monitor and ECG gated SPECT at the end of 12 months. The gated SPECT images demonstrated mild but definitely improved tracer uptake within part of the infarcted segments along with improvement in ejection fraction to 45%, and a clinical change in the NYHA Class to II. Cell-based therapy may offer benefits of induction of normal tissue microenvironment. Medknow Publications Pvt Ltd 2011 /pmc/articles/PMC3144623/ /pubmed/21814420 http://dx.doi.org/10.4103/0975-3583.83037 Text en © Journal of Cardiovascular Disease Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Case Report Based Study Gokhale, Alla Gopala Krishna Chelluri, Lakshmi Kiran Kumaresan, K. Subramanyam, G. Sudhakar, K. Vemuri, Sathish Debnath, Tanya Ratnakar, K. S. Evaluation of the autologous bone marrow mononuclear therapy and functional restoration in the scarred myocardium by imaging analysis |
title | Evaluation of the autologous bone marrow mononuclear therapy and functional restoration in the scarred myocardium by imaging analysis |
title_full | Evaluation of the autologous bone marrow mononuclear therapy and functional restoration in the scarred myocardium by imaging analysis |
title_fullStr | Evaluation of the autologous bone marrow mononuclear therapy and functional restoration in the scarred myocardium by imaging analysis |
title_full_unstemmed | Evaluation of the autologous bone marrow mononuclear therapy and functional restoration in the scarred myocardium by imaging analysis |
title_short | Evaluation of the autologous bone marrow mononuclear therapy and functional restoration in the scarred myocardium by imaging analysis |
title_sort | evaluation of the autologous bone marrow mononuclear therapy and functional restoration in the scarred myocardium by imaging analysis |
topic | Clinical Case Report Based Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144623/ https://www.ncbi.nlm.nih.gov/pubmed/21814420 http://dx.doi.org/10.4103/0975-3583.83037 |
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