Cargando…

Nonsegmental Vitiligo and Autoimmune Mechanism

Nonsegmental vitiligo is a depigmented skin disorder showing acquired, progressive, and depigmented lesions of the skin, mucosa, and hair. It is believed to be caused mainly by the autoimmune loss of melanocytes from the involved areas. It is frequently associated with other autoimmune diseases, par...

Descripción completa

Detalles Bibliográficos
Autores principales: Oiso, Naoki, Suzuki, Tamio, Fukai, Kazuyoshi, Katayama, Ichiro, Kawada, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144695/
https://www.ncbi.nlm.nih.gov/pubmed/21804820
http://dx.doi.org/10.1155/2011/518090
_version_ 1782209028876664832
author Oiso, Naoki
Suzuki, Tamio
Fukai, Kazuyoshi
Katayama, Ichiro
Kawada, Akira
author_facet Oiso, Naoki
Suzuki, Tamio
Fukai, Kazuyoshi
Katayama, Ichiro
Kawada, Akira
author_sort Oiso, Naoki
collection PubMed
description Nonsegmental vitiligo is a depigmented skin disorder showing acquired, progressive, and depigmented lesions of the skin, mucosa, and hair. It is believed to be caused mainly by the autoimmune loss of melanocytes from the involved areas. It is frequently associated with other autoimmune diseases, particularly autoimmune thyroid diseases including Hashimoto's thyroiditis and Graves' disease, rheumatoid arthritis, type 1 diabetes, psoriasis, pernicious anemia, systemic lupus erythematosus, Addison's disease, and alopecia areata. This indicates the presence of genetically determined susceptibility to not only vitiligo but also to other autoimmune disorders. Here, we summarize current understanding of autoimmune pathogenesis in non-segmental vitiligo.
format Online
Article
Text
id pubmed-3144695
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-31446952011-07-29 Nonsegmental Vitiligo and Autoimmune Mechanism Oiso, Naoki Suzuki, Tamio Fukai, Kazuyoshi Katayama, Ichiro Kawada, Akira Dermatol Res Pract Review Article Nonsegmental vitiligo is a depigmented skin disorder showing acquired, progressive, and depigmented lesions of the skin, mucosa, and hair. It is believed to be caused mainly by the autoimmune loss of melanocytes from the involved areas. It is frequently associated with other autoimmune diseases, particularly autoimmune thyroid diseases including Hashimoto's thyroiditis and Graves' disease, rheumatoid arthritis, type 1 diabetes, psoriasis, pernicious anemia, systemic lupus erythematosus, Addison's disease, and alopecia areata. This indicates the presence of genetically determined susceptibility to not only vitiligo but also to other autoimmune disorders. Here, we summarize current understanding of autoimmune pathogenesis in non-segmental vitiligo. Hindawi Publishing Corporation 2011 2011-07-26 /pmc/articles/PMC3144695/ /pubmed/21804820 http://dx.doi.org/10.1155/2011/518090 Text en Copyright © 2011 Naoki Oiso et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Oiso, Naoki
Suzuki, Tamio
Fukai, Kazuyoshi
Katayama, Ichiro
Kawada, Akira
Nonsegmental Vitiligo and Autoimmune Mechanism
title Nonsegmental Vitiligo and Autoimmune Mechanism
title_full Nonsegmental Vitiligo and Autoimmune Mechanism
title_fullStr Nonsegmental Vitiligo and Autoimmune Mechanism
title_full_unstemmed Nonsegmental Vitiligo and Autoimmune Mechanism
title_short Nonsegmental Vitiligo and Autoimmune Mechanism
title_sort nonsegmental vitiligo and autoimmune mechanism
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144695/
https://www.ncbi.nlm.nih.gov/pubmed/21804820
http://dx.doi.org/10.1155/2011/518090
work_keys_str_mv AT oisonaoki nonsegmentalvitiligoandautoimmunemechanism
AT suzukitamio nonsegmentalvitiligoandautoimmunemechanism
AT fukaikazuyoshi nonsegmentalvitiligoandautoimmunemechanism
AT katayamaichiro nonsegmentalvitiligoandautoimmunemechanism
AT kawadaakira nonsegmentalvitiligoandautoimmunemechanism