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Efficacy of Chronic Antidepressant Treatments in a New Model of Extreme Anxiety in Rats
Animal models of anxious disorders found in humans, such as panic disorder and posttraumatic stress disorder, usually include spontaneous and conditioned fear that triggers escape and avoidance behaviors. The development of a panic disorder model with a learned component should increase knowledge of...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144710/ https://www.ncbi.nlm.nih.gov/pubmed/21808731 http://dx.doi.org/10.1155/2011/531435 |
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author | Javelot, Hervé Weiner, Luisa Terramorsi, Roxane Rougeot, Catherine Lalonde, Robert Messaoudi, Michaël |
author_facet | Javelot, Hervé Weiner, Luisa Terramorsi, Roxane Rougeot, Catherine Lalonde, Robert Messaoudi, Michaël |
author_sort | Javelot, Hervé |
collection | PubMed |
description | Animal models of anxious disorders found in humans, such as panic disorder and posttraumatic stress disorder, usually include spontaneous and conditioned fear that triggers escape and avoidance behaviors. The development of a panic disorder model with a learned component should increase knowledge of mechanisms involved in anxiety disorders. In our ethological model of extreme anxiety in the rat, forced apnea was combined with cold water vaporization in an inescapable situation. Based on the reactions of vehicle controls, behaviors involved in paroxysmic fear were passive (freezing) and active (jumping) reactions. Our results show that subchronic fluoxetine (5 mg/kg, IP, 21 days) and imipramine (10 mg/kg, IP, 14 days) administration alleviated freezing and jumping behaviors, whereas acute fluoxetine (1 mg/kg, IP) provoked opposite effects. Acute low dose of diazepam (1 mg/kg, IP) was not effective, whereas the higher dose of 3 mg/kg, IP, and clonazepam (1 mg/kg, IP) only had an effect on jumping. Paroxysmic fear generated in this experimental condition may therefore mimic the symptomatology observed in patients with anxiety disorders. |
format | Online Article Text |
id | pubmed-3144710 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-31447102011-08-01 Efficacy of Chronic Antidepressant Treatments in a New Model of Extreme Anxiety in Rats Javelot, Hervé Weiner, Luisa Terramorsi, Roxane Rougeot, Catherine Lalonde, Robert Messaoudi, Michaël Depress Res Treat Research Article Animal models of anxious disorders found in humans, such as panic disorder and posttraumatic stress disorder, usually include spontaneous and conditioned fear that triggers escape and avoidance behaviors. The development of a panic disorder model with a learned component should increase knowledge of mechanisms involved in anxiety disorders. In our ethological model of extreme anxiety in the rat, forced apnea was combined with cold water vaporization in an inescapable situation. Based on the reactions of vehicle controls, behaviors involved in paroxysmic fear were passive (freezing) and active (jumping) reactions. Our results show that subchronic fluoxetine (5 mg/kg, IP, 21 days) and imipramine (10 mg/kg, IP, 14 days) administration alleviated freezing and jumping behaviors, whereas acute fluoxetine (1 mg/kg, IP) provoked opposite effects. Acute low dose of diazepam (1 mg/kg, IP) was not effective, whereas the higher dose of 3 mg/kg, IP, and clonazepam (1 mg/kg, IP) only had an effect on jumping. Paroxysmic fear generated in this experimental condition may therefore mimic the symptomatology observed in patients with anxiety disorders. Hindawi Publishing Corporation 2011 2011-07-26 /pmc/articles/PMC3144710/ /pubmed/21808731 http://dx.doi.org/10.1155/2011/531435 Text en Copyright © 2011 Hervé Javelot et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Javelot, Hervé Weiner, Luisa Terramorsi, Roxane Rougeot, Catherine Lalonde, Robert Messaoudi, Michaël Efficacy of Chronic Antidepressant Treatments in a New Model of Extreme Anxiety in Rats |
title | Efficacy of Chronic Antidepressant Treatments in a New Model of Extreme Anxiety in Rats |
title_full | Efficacy of Chronic Antidepressant Treatments in a New Model of Extreme Anxiety in Rats |
title_fullStr | Efficacy of Chronic Antidepressant Treatments in a New Model of Extreme Anxiety in Rats |
title_full_unstemmed | Efficacy of Chronic Antidepressant Treatments in a New Model of Extreme Anxiety in Rats |
title_short | Efficacy of Chronic Antidepressant Treatments in a New Model of Extreme Anxiety in Rats |
title_sort | efficacy of chronic antidepressant treatments in a new model of extreme anxiety in rats |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144710/ https://www.ncbi.nlm.nih.gov/pubmed/21808731 http://dx.doi.org/10.1155/2011/531435 |
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