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Efficacy of Chronic Antidepressant Treatments in a New Model of Extreme Anxiety in Rats

Animal models of anxious disorders found in humans, such as panic disorder and posttraumatic stress disorder, usually include spontaneous and conditioned fear that triggers escape and avoidance behaviors. The development of a panic disorder model with a learned component should increase knowledge of...

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Autores principales: Javelot, Hervé, Weiner, Luisa, Terramorsi, Roxane, Rougeot, Catherine, Lalonde, Robert, Messaoudi, Michaël
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144710/
https://www.ncbi.nlm.nih.gov/pubmed/21808731
http://dx.doi.org/10.1155/2011/531435
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author Javelot, Hervé
Weiner, Luisa
Terramorsi, Roxane
Rougeot, Catherine
Lalonde, Robert
Messaoudi, Michaël
author_facet Javelot, Hervé
Weiner, Luisa
Terramorsi, Roxane
Rougeot, Catherine
Lalonde, Robert
Messaoudi, Michaël
author_sort Javelot, Hervé
collection PubMed
description Animal models of anxious disorders found in humans, such as panic disorder and posttraumatic stress disorder, usually include spontaneous and conditioned fear that triggers escape and avoidance behaviors. The development of a panic disorder model with a learned component should increase knowledge of mechanisms involved in anxiety disorders. In our ethological model of extreme anxiety in the rat, forced apnea was combined with cold water vaporization in an inescapable situation. Based on the reactions of vehicle controls, behaviors involved in paroxysmic fear were passive (freezing) and active (jumping) reactions. Our results show that subchronic fluoxetine (5 mg/kg, IP, 21 days) and imipramine (10 mg/kg, IP, 14 days) administration alleviated freezing and jumping behaviors, whereas acute fluoxetine (1 mg/kg, IP) provoked opposite effects. Acute low dose of diazepam (1 mg/kg, IP) was not effective, whereas the higher dose of 3 mg/kg, IP, and clonazepam (1 mg/kg, IP) only had an effect on jumping. Paroxysmic fear generated in this experimental condition may therefore mimic the symptomatology observed in patients with anxiety disorders.
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spelling pubmed-31447102011-08-01 Efficacy of Chronic Antidepressant Treatments in a New Model of Extreme Anxiety in Rats Javelot, Hervé Weiner, Luisa Terramorsi, Roxane Rougeot, Catherine Lalonde, Robert Messaoudi, Michaël Depress Res Treat Research Article Animal models of anxious disorders found in humans, such as panic disorder and posttraumatic stress disorder, usually include spontaneous and conditioned fear that triggers escape and avoidance behaviors. The development of a panic disorder model with a learned component should increase knowledge of mechanisms involved in anxiety disorders. In our ethological model of extreme anxiety in the rat, forced apnea was combined with cold water vaporization in an inescapable situation. Based on the reactions of vehicle controls, behaviors involved in paroxysmic fear were passive (freezing) and active (jumping) reactions. Our results show that subchronic fluoxetine (5 mg/kg, IP, 21 days) and imipramine (10 mg/kg, IP, 14 days) administration alleviated freezing and jumping behaviors, whereas acute fluoxetine (1 mg/kg, IP) provoked opposite effects. Acute low dose of diazepam (1 mg/kg, IP) was not effective, whereas the higher dose of 3 mg/kg, IP, and clonazepam (1 mg/kg, IP) only had an effect on jumping. Paroxysmic fear generated in this experimental condition may therefore mimic the symptomatology observed in patients with anxiety disorders. Hindawi Publishing Corporation 2011 2011-07-26 /pmc/articles/PMC3144710/ /pubmed/21808731 http://dx.doi.org/10.1155/2011/531435 Text en Copyright © 2011 Hervé Javelot et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Javelot, Hervé
Weiner, Luisa
Terramorsi, Roxane
Rougeot, Catherine
Lalonde, Robert
Messaoudi, Michaël
Efficacy of Chronic Antidepressant Treatments in a New Model of Extreme Anxiety in Rats
title Efficacy of Chronic Antidepressant Treatments in a New Model of Extreme Anxiety in Rats
title_full Efficacy of Chronic Antidepressant Treatments in a New Model of Extreme Anxiety in Rats
title_fullStr Efficacy of Chronic Antidepressant Treatments in a New Model of Extreme Anxiety in Rats
title_full_unstemmed Efficacy of Chronic Antidepressant Treatments in a New Model of Extreme Anxiety in Rats
title_short Efficacy of Chronic Antidepressant Treatments in a New Model of Extreme Anxiety in Rats
title_sort efficacy of chronic antidepressant treatments in a new model of extreme anxiety in rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144710/
https://www.ncbi.nlm.nih.gov/pubmed/21808731
http://dx.doi.org/10.1155/2011/531435
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