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Survival in patients with synchronous liver metastases in central and northern Denmark, 1998 to 2009
OBJECTIVE: In Denmark, the strategy for treatment of cancer with metastases to the liver has changed dramatically during the period 1998 to 2009, when multidisciplinary care and a number of new treatments were introduced. We therefore examined the changes in survival in Danish patients with colorect...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144773/ https://www.ncbi.nlm.nih.gov/pubmed/21814465 http://dx.doi.org/10.2147/CLEP.S20613 |
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author | Høyer, Morten Erichsen, Rune Gandrup, Per Nørgaard, Mette Jacobsen, Jacob Bonde |
author_facet | Høyer, Morten Erichsen, Rune Gandrup, Per Nørgaard, Mette Jacobsen, Jacob Bonde |
author_sort | Høyer, Morten |
collection | PubMed |
description | OBJECTIVE: In Denmark, the strategy for treatment of cancer with metastases to the liver has changed dramatically during the period 1998 to 2009, when multidisciplinary care and a number of new treatments were introduced. We therefore examined the changes in survival in Danish patients with colorectal carcinoma (CRC) or other solid tumors (non-CRC) who had liver metastases at time of diagnosis. STUDY DESIGN AND METHODS: We included patients diagnosed with liver metastases synchronous with a primary cancer (ie, a solid cancer diagnosed at the same date or within 60 days after liver metastasis diagnosis) during the period 1998 to 2009 identified through the Danish National Registry of Patients. We followed those who survived for more than 60 days in a survival analysis (n = 1021). Survival and mortality rate ratio (MRR) at 1, 3, and 5 years stratified by year of diagnosis were estimated using Cox proportional hazards regression analysis. RESULTS: In the total study population of 1021 patients, 541 patients had a primary CRC and 480 patients non-CRC. Overall, the 5-year survival improved from 3% (95% confidence interval [CI]: 1%–6%) in 1998–2000 to 10% (95% CI: 6%–14%) in 2007 to 2009 (predicted value). The 5-year survival for CRC-patients improved from 1% (95% CI: 0%–5%) to 11% (95% CI: 6%–18%) whereas survival for non-CRC patients only increased from 5% (95% CI: 1%–10%) to 8% (95% CI: 4%–14%). CONCLUSION: We observed improved survival in patients with liver metastases in a time period characterized by introduction of a structured multidisciplinary care and improved treatment options. The survival gain was most prominent for CRC-patients. |
format | Online Article Text |
id | pubmed-3144773 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-31447732011-08-03 Survival in patients with synchronous liver metastases in central and northern Denmark, 1998 to 2009 Høyer, Morten Erichsen, Rune Gandrup, Per Nørgaard, Mette Jacobsen, Jacob Bonde Clin Epidemiol Original Research OBJECTIVE: In Denmark, the strategy for treatment of cancer with metastases to the liver has changed dramatically during the period 1998 to 2009, when multidisciplinary care and a number of new treatments were introduced. We therefore examined the changes in survival in Danish patients with colorectal carcinoma (CRC) or other solid tumors (non-CRC) who had liver metastases at time of diagnosis. STUDY DESIGN AND METHODS: We included patients diagnosed with liver metastases synchronous with a primary cancer (ie, a solid cancer diagnosed at the same date or within 60 days after liver metastasis diagnosis) during the period 1998 to 2009 identified through the Danish National Registry of Patients. We followed those who survived for more than 60 days in a survival analysis (n = 1021). Survival and mortality rate ratio (MRR) at 1, 3, and 5 years stratified by year of diagnosis were estimated using Cox proportional hazards regression analysis. RESULTS: In the total study population of 1021 patients, 541 patients had a primary CRC and 480 patients non-CRC. Overall, the 5-year survival improved from 3% (95% confidence interval [CI]: 1%–6%) in 1998–2000 to 10% (95% CI: 6%–14%) in 2007 to 2009 (predicted value). The 5-year survival for CRC-patients improved from 1% (95% CI: 0%–5%) to 11% (95% CI: 6%–18%) whereas survival for non-CRC patients only increased from 5% (95% CI: 1%–10%) to 8% (95% CI: 4%–14%). CONCLUSION: We observed improved survival in patients with liver metastases in a time period characterized by introduction of a structured multidisciplinary care and improved treatment options. The survival gain was most prominent for CRC-patients. Dove Medical Press 2011-07-20 /pmc/articles/PMC3144773/ /pubmed/21814465 http://dx.doi.org/10.2147/CLEP.S20613 Text en © 2011 Høyer et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Original Research Høyer, Morten Erichsen, Rune Gandrup, Per Nørgaard, Mette Jacobsen, Jacob Bonde Survival in patients with synchronous liver metastases in central and northern Denmark, 1998 to 2009 |
title | Survival in patients with synchronous liver metastases in central and northern Denmark, 1998 to 2009 |
title_full | Survival in patients with synchronous liver metastases in central and northern Denmark, 1998 to 2009 |
title_fullStr | Survival in patients with synchronous liver metastases in central and northern Denmark, 1998 to 2009 |
title_full_unstemmed | Survival in patients with synchronous liver metastases in central and northern Denmark, 1998 to 2009 |
title_short | Survival in patients with synchronous liver metastases in central and northern Denmark, 1998 to 2009 |
title_sort | survival in patients with synchronous liver metastases in central and northern denmark, 1998 to 2009 |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144773/ https://www.ncbi.nlm.nih.gov/pubmed/21814465 http://dx.doi.org/10.2147/CLEP.S20613 |
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