Use of the α-mannosidase I inhibitor kifunensine allows the crystallization of apo CTLA-4 homodimer produced in long-term cultures of Chinese hamster ovary cells

Glycoproteins present problems for structural analysis since they often have to be glycosylated in order to fold correctly and because their chemical and conformational heterogeneity generally inhibits crystallization. It is shown that the α-mannosidase I inhibitor kifunensine, which has previously...

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Detalles Bibliográficos
Autores principales: Yu, Chao, Crispin, Max, Sonnen, Andreas F.-P., Harvey, David J., Chang, Veronica T., Evans, Edward J., Scanlan, Christopher N., Stuart, David I., Gilbert, Robert J. C., Davis, Simon J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2011
Materias:
Crystallization Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144796/
https://www.ncbi.nlm.nih.gov/pubmed/21795794
http://dx.doi.org/10.1107/S1744309111017672

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