LGR5 Is a Negative Regulator of Tumourigenicity, Antagonizes Wnt Signalling and Regulates Cell Adhesion in Colorectal Cancer Cell Lines

BACKGROUND: LGR5 (Leucine-rich repeat-containing G-protein coupled receptor 5) is the most established marker for intestinal stem cells. Mouse models show that LGR5+ cells are the cells of origin of intestinal cancer, and LGR5 expression is elevated in human colorectal cancers, however very little i...

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Detalles Bibliográficos
Autores principales: Walker, Francesca, Zhang, Hui-Hua, Odorizzi, Annalisa, Burgess, Antony W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145754/
https://www.ncbi.nlm.nih.gov/pubmed/21829496
http://dx.doi.org/10.1371/journal.pone.0022733

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145754/
https://www.ncbi.nlm.nih.gov/pubmed/21829496
http://dx.doi.org/10.1371/journal.pone.0022733

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