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C-Terminal Region of EBNA-2 Determines the Superior Transforming Ability of Type 1 Epstein-Barr Virus by Enhanced Gene Regulation of LMP-1 and CXCR7

Type 1 Epstein-Barr virus (EBV) strains immortalize B lymphocytes in vitro much more efficiently than type 2 EBV, a difference previously mapped to the EBNA-2 locus. Here we demonstrate that the greater transforming activity of type 1 EBV correlates with a stronger and more rapid induction of the vi...

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Detalles Bibliográficos
Autores principales:	Cancian, Laila, Bosshard, Rachel, Lucchesi, Walter, Karstegl, Claudio Elgueta, Farrell, Paul J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145799/ https://www.ncbi.nlm.nih.gov/pubmed/21857817 http://dx.doi.org/10.1371/journal.ppat.1002164

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