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Diagnostic Value of C-reactive Protein in Complicated Appendicitis

PURPOSE: Early detection of appendicitis has increased due to development of computed tomography and ultrasonography, yet we are frequently meeting complicated appendicitis, including perforation, abscess and a gangrenous appendicitis due to delayed diagnosis. For that reason, we want to evaluate pr...

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Autores principales: Moon, Hyoung-Min, Park, Beom-Seok, Moon, Duk-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Coloproctology 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145882/
https://www.ncbi.nlm.nih.gov/pubmed/21829766
http://dx.doi.org/10.3393/jksc.2011.27.3.122
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author Moon, Hyoung-Min
Park, Beom-Seok
Moon, Duk-Jin
author_facet Moon, Hyoung-Min
Park, Beom-Seok
Moon, Duk-Jin
author_sort Moon, Hyoung-Min
collection PubMed
description PURPOSE: Early detection of appendicitis has increased due to development of computed tomography and ultrasonography, yet we are frequently meeting complicated appendicitis, including perforation, abscess and a gangrenous appendicitis due to delayed diagnosis. For that reason, we want to evaluate predictive factors for the complicated appendicitis. METHODS: A total of 128 patients with appendicitis, after 13 patients with a duration of under 12 hours and 15 patients with pathological non-appendicitis were excluded from 156 patients, who visited Kwangju Christian Hospital from November 2008 to November 2010 were retrospectively reviewed. RESULTS: There were 62 patients (48.3%) with simple appendicitis and 66 patients (51.7%) with complicated appendicitis. In univariate analysis, age (P < 0.001), C-reactive protein (P < 0.001) and the diameter of the appendix (P = 0.006), were found to be significant. Multivariate analysis demonstrated that C-reactive protein was an independent predictor for complicated appendicitis (odds ratio, 1.371; 95% confidence interval, 1.155 to 1.628; P < 0.001). The cut-off value of C-reactive protein was set at 7.05 mg/dL by using receiver operating characteristic curve (0.805; sensitivity, 57.6%; specificity, 98.3%). CONCLUSION: This study suggests that if C-reactive protein is above 7.05 mg/dL, immediate and proper management should be performed due to a high probability of complicated appendicitis, especially in young children or elderly patients who frequently present with vague symptoms.
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spelling pubmed-31458822011-08-09 Diagnostic Value of C-reactive Protein in Complicated Appendicitis Moon, Hyoung-Min Park, Beom-Seok Moon, Duk-Jin J Korean Soc Coloproctol Original Article PURPOSE: Early detection of appendicitis has increased due to development of computed tomography and ultrasonography, yet we are frequently meeting complicated appendicitis, including perforation, abscess and a gangrenous appendicitis due to delayed diagnosis. For that reason, we want to evaluate predictive factors for the complicated appendicitis. METHODS: A total of 128 patients with appendicitis, after 13 patients with a duration of under 12 hours and 15 patients with pathological non-appendicitis were excluded from 156 patients, who visited Kwangju Christian Hospital from November 2008 to November 2010 were retrospectively reviewed. RESULTS: There were 62 patients (48.3%) with simple appendicitis and 66 patients (51.7%) with complicated appendicitis. In univariate analysis, age (P < 0.001), C-reactive protein (P < 0.001) and the diameter of the appendix (P = 0.006), were found to be significant. Multivariate analysis demonstrated that C-reactive protein was an independent predictor for complicated appendicitis (odds ratio, 1.371; 95% confidence interval, 1.155 to 1.628; P < 0.001). The cut-off value of C-reactive protein was set at 7.05 mg/dL by using receiver operating characteristic curve (0.805; sensitivity, 57.6%; specificity, 98.3%). CONCLUSION: This study suggests that if C-reactive protein is above 7.05 mg/dL, immediate and proper management should be performed due to a high probability of complicated appendicitis, especially in young children or elderly patients who frequently present with vague symptoms. The Korean Society of Coloproctology 2011-06 2011-06-30 /pmc/articles/PMC3145882/ /pubmed/21829766 http://dx.doi.org/10.3393/jksc.2011.27.3.122 Text en © 2011 The Korean Society of Coloproctology http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Moon, Hyoung-Min
Park, Beom-Seok
Moon, Duk-Jin
Diagnostic Value of C-reactive Protein in Complicated Appendicitis
title Diagnostic Value of C-reactive Protein in Complicated Appendicitis
title_full Diagnostic Value of C-reactive Protein in Complicated Appendicitis
title_fullStr Diagnostic Value of C-reactive Protein in Complicated Appendicitis
title_full_unstemmed Diagnostic Value of C-reactive Protein in Complicated Appendicitis
title_short Diagnostic Value of C-reactive Protein in Complicated Appendicitis
title_sort diagnostic value of c-reactive protein in complicated appendicitis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145882/
https://www.ncbi.nlm.nih.gov/pubmed/21829766
http://dx.doi.org/10.3393/jksc.2011.27.3.122
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