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MPP(+)-induced toxicity in the presence of dopamine is mediated by COX-2 through oxidative stress
Accumulating evidence suggests that endogenous dopamine may act as a neurotoxin and thereby participate in the pathophysiology of Parkinson’s disease (PD). Cyclooxygenase-2 (COX-2) has been implicated in the pathogenesis of PD due to its ability to generate reactive oxygen species (ROS). Inhibition...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer-Verlag
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145900/ https://www.ncbi.nlm.nih.gov/pubmed/21667279 http://dx.doi.org/10.1007/s00210-011-0660-8 |