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QSAR studies of benzofuran/benzothiophene biphenyl derivatives as inhibitors of PTPase-1B
OBJECTIVES: Insulin resistance is associated with a defect in protein tyrosine phosphorylation in the insulin signal transduction cascade. The PTPase enzyme dephosphorylates the active form of the insulin receptor and thus attenuates its tyrosine kinase activity, therefore, the need for a potent PTP...
Autores principales: | Kaushik, D., Kumar, R., Saxena, A. K. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications Pvt Ltd
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146088/ https://www.ncbi.nlm.nih.gov/pubmed/21814427 http://dx.doi.org/10.4103/0975-7406.62703 |
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