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QSAR studies of benzofuran/benzothiophene biphenyl derivatives as inhibitors of PTPase-1B

OBJECTIVES: Insulin resistance is associated with a defect in protein tyrosine phosphorylation in the insulin signal transduction cascade. The PTPase enzyme dephosphorylates the active form of the insulin receptor and thus attenuates its tyrosine kinase activity, therefore, the need for a potent PTP...

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Detalles Bibliográficos
Autores principales:	Kaushik, D., Kumar, R., Saxena, A. K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Medknow Publications Pvt Ltd 2010
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146088/ https://www.ncbi.nlm.nih.gov/pubmed/21814427 http://dx.doi.org/10.4103/0975-7406.62703

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