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Endogenous PTH Deficiency Impairs Fracture Healing and Impedes the Fracture-Healing Efficacy of Exogenous PTH(1-34)

BACKGROUND: Although the capacity of exogenous PTH1-34 to enhance the rate of bone repair is well established in animal models, our understanding of the mechanism(s) whereby PTH induces an anabolic response during skeletal repair remains limited. Furthermore it is unknown whether endogenous PTH is r...

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Detalles Bibliográficos
Autores principales: Ren, Yongxin, Liu, Bo, Feng, Yuxu, Shu, Lei, Cao, Xiaojian, Karaplis, Andrew, Goltzman, David, Miao, Dengshun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146536/
https://www.ncbi.nlm.nih.gov/pubmed/21829585
http://dx.doi.org/10.1371/journal.pone.0023060