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Nucleotide receptors as targets in the pharmacological enhancement of dermal wound healing
With a growing interest of the involvement of extracellular nucleotides in both normal physiology and pathology, it has become evident that P2 receptor agonists and antagonists may have therapeutic potential. The P2Y2 receptor agonists (diquafosol tetrasodium and denufosol tetrasodium) are in the ph...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Netherlands
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146642/ https://www.ncbi.nlm.nih.gov/pubmed/21519856 http://dx.doi.org/10.1007/s11302-011-9233-z |
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author | Gendaszewska-Darmach, Edyta Kucharska, Marta |
author_facet | Gendaszewska-Darmach, Edyta Kucharska, Marta |
author_sort | Gendaszewska-Darmach, Edyta |
collection | PubMed |
description | With a growing interest of the involvement of extracellular nucleotides in both normal physiology and pathology, it has become evident that P2 receptor agonists and antagonists may have therapeutic potential. The P2Y2 receptor agonists (diquafosol tetrasodium and denufosol tetrasodium) are in the phase 3 of clinical trials for dry eye and cystic fibrosis, respectively. The thienopyridine derivatives clopidogrel and ticlopidine (antagonists of the platelet P2Y12 receptor) have been used in cardiovascular medicine for nearly a decade. Purines and pyrimidines may be of therapeutic potential also in wound healing since ATP and UTP have been shown to have many hallmarks of wound healing factors. Recent studies have demonstrated that extracellular nucleotides take part in all phases of wound repair: hemostasis, inflammation, tissue formation, and tissue remodeling. This review is focused on the potent purines and pyrimidines which regulate many physiological processes important for wound healing. |
format | Online Article Text |
id | pubmed-3146642 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Springer Netherlands |
record_format | MEDLINE/PubMed |
spelling | pubmed-31466422011-09-26 Nucleotide receptors as targets in the pharmacological enhancement of dermal wound healing Gendaszewska-Darmach, Edyta Kucharska, Marta Purinergic Signal Review With a growing interest of the involvement of extracellular nucleotides in both normal physiology and pathology, it has become evident that P2 receptor agonists and antagonists may have therapeutic potential. The P2Y2 receptor agonists (diquafosol tetrasodium and denufosol tetrasodium) are in the phase 3 of clinical trials for dry eye and cystic fibrosis, respectively. The thienopyridine derivatives clopidogrel and ticlopidine (antagonists of the platelet P2Y12 receptor) have been used in cardiovascular medicine for nearly a decade. Purines and pyrimidines may be of therapeutic potential also in wound healing since ATP and UTP have been shown to have many hallmarks of wound healing factors. Recent studies have demonstrated that extracellular nucleotides take part in all phases of wound repair: hemostasis, inflammation, tissue formation, and tissue remodeling. This review is focused on the potent purines and pyrimidines which regulate many physiological processes important for wound healing. Springer Netherlands 2011-04-26 2011-06 /pmc/articles/PMC3146642/ /pubmed/21519856 http://dx.doi.org/10.1007/s11302-011-9233-z Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Review Gendaszewska-Darmach, Edyta Kucharska, Marta Nucleotide receptors as targets in the pharmacological enhancement of dermal wound healing |
title | Nucleotide receptors as targets in the pharmacological enhancement of dermal wound healing |
title_full | Nucleotide receptors as targets in the pharmacological enhancement of dermal wound healing |
title_fullStr | Nucleotide receptors as targets in the pharmacological enhancement of dermal wound healing |
title_full_unstemmed | Nucleotide receptors as targets in the pharmacological enhancement of dermal wound healing |
title_short | Nucleotide receptors as targets in the pharmacological enhancement of dermal wound healing |
title_sort | nucleotide receptors as targets in the pharmacological enhancement of dermal wound healing |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146642/ https://www.ncbi.nlm.nih.gov/pubmed/21519856 http://dx.doi.org/10.1007/s11302-011-9233-z |
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