Neuroregeneration in neurodegenerative disorders

BACKGROUND: Neuroregeneration is a relatively recent concept that includes neurogenesis, neuroplasticity, and neurorestoration - implantation of viable cells as a therapeutical approach. DISCUSSION: Neurogenesis and neuroplasticity are impaired in brains of patients suffering from Alzheimer's D...

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Detalles Bibliográficos
Autores principales: Enciu, Ana M, Nicolescu, Mihnea I, Manole, Catalin G, Mureşanu, Dafin F, Popescu, Laurenţiu M, Popescu, Bogdan O
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Debate
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146817/
https://www.ncbi.nlm.nih.gov/pubmed/21699711
http://dx.doi.org/10.1186/1471-2377-11-75
Descripción
Sumario:BACKGROUND: Neuroregeneration is a relatively recent concept that includes neurogenesis, neuroplasticity, and neurorestoration - implantation of viable cells as a therapeutical approach. DISCUSSION: Neurogenesis and neuroplasticity are impaired in brains of patients suffering from Alzheimer's Disease or Parkinson's Disease and correlate with low endogenous protection, as a result of a diminished growth factors expression. However, we hypothesize that the brain possesses, at least in early and medium stages of disease, a "neuroregenerative reserve", that could be exploited by growth factors or stem cells-neurorestoration therapies. SUMMARY: In this paper we review the current data regarding all three aspects of neuroregeneration in Alzheimer's Disease and Parkinson's Disease.

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