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Neuroregeneration in neurodegenerative disorders

BACKGROUND: Neuroregeneration is a relatively recent concept that includes neurogenesis, neuroplasticity, and neurorestoration - implantation of viable cells as a therapeutical approach. DISCUSSION: Neurogenesis and neuroplasticity are impaired in brains of patients suffering from Alzheimer's D...

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Autores principales: Enciu, Ana M, Nicolescu, Mihnea I, Manole, Catalin G, Mureşanu, Dafin F, Popescu, Laurenţiu M, Popescu, Bogdan O
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146817/
https://www.ncbi.nlm.nih.gov/pubmed/21699711
http://dx.doi.org/10.1186/1471-2377-11-75
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author Enciu, Ana M
Nicolescu, Mihnea I
Manole, Catalin G
Mureşanu, Dafin F
Popescu, Laurenţiu M
Popescu, Bogdan O
author_facet Enciu, Ana M
Nicolescu, Mihnea I
Manole, Catalin G
Mureşanu, Dafin F
Popescu, Laurenţiu M
Popescu, Bogdan O
author_sort Enciu, Ana M
collection PubMed
description BACKGROUND: Neuroregeneration is a relatively recent concept that includes neurogenesis, neuroplasticity, and neurorestoration - implantation of viable cells as a therapeutical approach. DISCUSSION: Neurogenesis and neuroplasticity are impaired in brains of patients suffering from Alzheimer's Disease or Parkinson's Disease and correlate with low endogenous protection, as a result of a diminished growth factors expression. However, we hypothesize that the brain possesses, at least in early and medium stages of disease, a "neuroregenerative reserve", that could be exploited by growth factors or stem cells-neurorestoration therapies. SUMMARY: In this paper we review the current data regarding all three aspects of neuroregeneration in Alzheimer's Disease and Parkinson's Disease.
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spelling pubmed-31468172011-07-31 Neuroregeneration in neurodegenerative disorders Enciu, Ana M Nicolescu, Mihnea I Manole, Catalin G Mureşanu, Dafin F Popescu, Laurenţiu M Popescu, Bogdan O BMC Neurol Debate BACKGROUND: Neuroregeneration is a relatively recent concept that includes neurogenesis, neuroplasticity, and neurorestoration - implantation of viable cells as a therapeutical approach. DISCUSSION: Neurogenesis and neuroplasticity are impaired in brains of patients suffering from Alzheimer's Disease or Parkinson's Disease and correlate with low endogenous protection, as a result of a diminished growth factors expression. However, we hypothesize that the brain possesses, at least in early and medium stages of disease, a "neuroregenerative reserve", that could be exploited by growth factors or stem cells-neurorestoration therapies. SUMMARY: In this paper we review the current data regarding all three aspects of neuroregeneration in Alzheimer's Disease and Parkinson's Disease. BioMed Central 2011-06-23 /pmc/articles/PMC3146817/ /pubmed/21699711 http://dx.doi.org/10.1186/1471-2377-11-75 Text en Copyright ©2011 Enciu et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Debate
Enciu, Ana M
Nicolescu, Mihnea I
Manole, Catalin G
Mureşanu, Dafin F
Popescu, Laurenţiu M
Popescu, Bogdan O
Neuroregeneration in neurodegenerative disorders
title Neuroregeneration in neurodegenerative disorders
title_full Neuroregeneration in neurodegenerative disorders
title_fullStr Neuroregeneration in neurodegenerative disorders
title_full_unstemmed Neuroregeneration in neurodegenerative disorders
title_short Neuroregeneration in neurodegenerative disorders
title_sort neuroregeneration in neurodegenerative disorders
topic Debate
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146817/
https://www.ncbi.nlm.nih.gov/pubmed/21699711
http://dx.doi.org/10.1186/1471-2377-11-75
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