High Chromosome Number in hematological cancer cell lines is a Negative Predictor of Response to the inhibition of Aurora B and C by GSK1070916

BACKGROUND: Aurora kinases play critical roles in mitosis and are being evaluated as therapeutic targets in cancer. GSK1070916 is a potent, selective, ATP competitive inhibitor of Aurora kinase B and C. Translation of predictive biomarkers to the clinic can benefit patients by identifying the tumors...

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Detalles Bibliográficos
Autores principales: Moy, Christopher, Oleykowski, Catherine A, Plant, Ramona, Greshock, Joel, Jing, Junping, Bachman, Kurtis, Hardwicke, Mary Ann, Wooster, Richard, Degenhardt, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146841/
https://www.ncbi.nlm.nih.gov/pubmed/21762492
http://dx.doi.org/10.1186/1479-5876-9-110

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