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Antiobesity and lipid-lowering effects of Bifidobacterium spp. in high fat diet-induced obese rats
BACKGROUND: Recent studies have reported the preventive effects of probiotics on obesity. Among commensal bacteria, bifidobacteria is one of the most numerous probiotics in the mammalian gut and are a type of lactic acid bacteria. The aim of this study was to assess the antiobesity and lipid-lowerin...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146849/ https://www.ncbi.nlm.nih.gov/pubmed/21745411 http://dx.doi.org/10.1186/1476-511X-10-116 |
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author | An, Hyang Mi Park, Shin Young Lee, Do Kyung Kim, Jung Rae Cha, Min Kyeong Lee, Si Won Lim, Hyung Taeck Kim, Kyung Jae Ha, Nam Joo |
author_facet | An, Hyang Mi Park, Shin Young Lee, Do Kyung Kim, Jung Rae Cha, Min Kyeong Lee, Si Won Lim, Hyung Taeck Kim, Kyung Jae Ha, Nam Joo |
author_sort | An, Hyang Mi |
collection | PubMed |
description | BACKGROUND: Recent studies have reported the preventive effects of probiotics on obesity. Among commensal bacteria, bifidobacteria is one of the most numerous probiotics in the mammalian gut and are a type of lactic acid bacteria. The aim of this study was to assess the antiobesity and lipid-lowering effects of Bifidobacterium spp. isolated from healthy Korean on high fat diet-induced obese rats. METHODS: Thirty-six male Sprague-Dawley rats were divided into three groups as follows: (1) SD group, fed standard diet; (2) HFD group, fed high fat diet; and (3) HFD-LAB group, fed high fat diet supplemented with LAB supplement (B. pseudocatenulatum SPM 1204, B. longum SPM 1205, and B. longum SPM 1207; 10(8 )~ 10(9 )CFU). After 7 weeks, the body, organ, and fat weights, food intake, blood serum levels, fecal LAB counts, and harmful enzyme activities were measured. RESULTS: Administration of LAB reduced body and fat weights, blood serum levels (TC, HDL-C, LDL-C, triglyceride, glucose, leptin, AST, ALT, and lipase levels), and harmful enzyme activities (β-glucosidase, β-glucuronidase, and tryptophanase), and significantly increased fecal LAB counts. CONCLUSION: These data suggest that Bifidobacterium spp. used in this study may have beneficial antiobesity effects. |
format | Online Article Text |
id | pubmed-3146849 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-31468492011-07-31 Antiobesity and lipid-lowering effects of Bifidobacterium spp. in high fat diet-induced obese rats An, Hyang Mi Park, Shin Young Lee, Do Kyung Kim, Jung Rae Cha, Min Kyeong Lee, Si Won Lim, Hyung Taeck Kim, Kyung Jae Ha, Nam Joo Lipids Health Dis Research BACKGROUND: Recent studies have reported the preventive effects of probiotics on obesity. Among commensal bacteria, bifidobacteria is one of the most numerous probiotics in the mammalian gut and are a type of lactic acid bacteria. The aim of this study was to assess the antiobesity and lipid-lowering effects of Bifidobacterium spp. isolated from healthy Korean on high fat diet-induced obese rats. METHODS: Thirty-six male Sprague-Dawley rats were divided into three groups as follows: (1) SD group, fed standard diet; (2) HFD group, fed high fat diet; and (3) HFD-LAB group, fed high fat diet supplemented with LAB supplement (B. pseudocatenulatum SPM 1204, B. longum SPM 1205, and B. longum SPM 1207; 10(8 )~ 10(9 )CFU). After 7 weeks, the body, organ, and fat weights, food intake, blood serum levels, fecal LAB counts, and harmful enzyme activities were measured. RESULTS: Administration of LAB reduced body and fat weights, blood serum levels (TC, HDL-C, LDL-C, triglyceride, glucose, leptin, AST, ALT, and lipase levels), and harmful enzyme activities (β-glucosidase, β-glucuronidase, and tryptophanase), and significantly increased fecal LAB counts. CONCLUSION: These data suggest that Bifidobacterium spp. used in this study may have beneficial antiobesity effects. BioMed Central 2011-07-12 /pmc/articles/PMC3146849/ /pubmed/21745411 http://dx.doi.org/10.1186/1476-511X-10-116 Text en Copyright ©2011 An et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research An, Hyang Mi Park, Shin Young Lee, Do Kyung Kim, Jung Rae Cha, Min Kyeong Lee, Si Won Lim, Hyung Taeck Kim, Kyung Jae Ha, Nam Joo Antiobesity and lipid-lowering effects of Bifidobacterium spp. in high fat diet-induced obese rats |
title | Antiobesity and lipid-lowering effects of Bifidobacterium spp. in high fat diet-induced obese rats |
title_full | Antiobesity and lipid-lowering effects of Bifidobacterium spp. in high fat diet-induced obese rats |
title_fullStr | Antiobesity and lipid-lowering effects of Bifidobacterium spp. in high fat diet-induced obese rats |
title_full_unstemmed | Antiobesity and lipid-lowering effects of Bifidobacterium spp. in high fat diet-induced obese rats |
title_short | Antiobesity and lipid-lowering effects of Bifidobacterium spp. in high fat diet-induced obese rats |
title_sort | antiobesity and lipid-lowering effects of bifidobacterium spp. in high fat diet-induced obese rats |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146849/ https://www.ncbi.nlm.nih.gov/pubmed/21745411 http://dx.doi.org/10.1186/1476-511X-10-116 |
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