A high-throughput protocol for mutation scanning of the BRCA1 and BRCA2 genes

BACKGROUND: Detection of mutations by DNA sequencing can be facilitated by scanning methods to identify amplicons which may have mutations. Current scanning methods used for the detection of germline sequence variants are laborious as they require post-PCR manipulation. High resolution melting (HRM)...

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Detalles Bibliográficos
Autores principales: Hondow, Heather L, Fox, Stephen B, Mitchell, Gillian, Scott, Rodney J, Beshay, Victoria, Wong, Stephen Q, Dobrovic, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Technical Advance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146935/
https://www.ncbi.nlm.nih.gov/pubmed/21702907
http://dx.doi.org/10.1186/1471-2407-11-265

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146935/
https://www.ncbi.nlm.nih.gov/pubmed/21702907
http://dx.doi.org/10.1186/1471-2407-11-265

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