Cucurbitacin-I (JSI-124) activates the JNK/c-Jun signaling pathway independent of apoptosis and cell cycle arrest in B Leukemic Cells

BACKGROUND: Cucurbitacin-I (JSI-124) is potent inhibitor of JAK/STAT3 signaling pathway and has anti-tumor activity in a variety of cancer including B cell leukemia. However, other molecular targets of JSI-124 beyond the JAK/STAT3 pathway are not fully understood. METHODS: BJAB, I-83, NALM-6 and pri...

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Detalles Bibliográficos
Autores principales: Ishdorj, Ganchimeg, Johnston, James B, Gibson, Spencer B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146936/
https://www.ncbi.nlm.nih.gov/pubmed/21702955
http://dx.doi.org/10.1186/1471-2407-11-268

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146936/
https://www.ncbi.nlm.nih.gov/pubmed/21702955
http://dx.doi.org/10.1186/1471-2407-11-268

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