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Synthetic emmprin peptides with chitobiose substitution stimulate MMP-2 production by fibroblasts

BACKGROUND: Emmprin, a glycoprotein containing two Ig domains, is enriched on tumor cell surfaces and stimulates matrix metalloproteinase (MMP) production by adjacent stromal cells. Its first Ig domain (ECI) contains the biologically active site. The dependence of emmprin activity on N-glycosylation...

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Detalles Bibliográficos
Autores principales:	Kawakami, Takehito, Sameshima, Tetsuro, Hojo, Hironobu, Koga, Kaori, Nakahara, Yoshiaki, Toole, Bryan P, Suzumiya, Junji, Okada, Yasunori, Iwasaki, Akinori, Nabeshima, Kazuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146944/ https://www.ncbi.nlm.nih.gov/pubmed/21762534 http://dx.doi.org/10.1186/1471-2407-11-300

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