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Chlamydia trachomatis and Mycoplasma genitalium Plasma Antibodies in Relation to Epithelial Ovarian Tumors

Objective. To assess associations of Chlamydia trachomatis and Mycoplasma genitalium antibodies with epithelial ovarian tumors. Methods. Plasma samples from 291 women, undergoing surgery due to suspected ovarian pathology, were analyzed with respect to C. trachomatis IgG and IgA, chlamydial Heat Sho...

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Autores principales: Idahl, Annika, Lundin, Eva, Jurstrand, Margaretha, Kumlin, Urban, Elgh, Fredrik, Ohlson, Nina, Ottander, Ulrika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3147007/
https://www.ncbi.nlm.nih.gov/pubmed/21811380
http://dx.doi.org/10.1155/2011/824627
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author Idahl, Annika
Lundin, Eva
Jurstrand, Margaretha
Kumlin, Urban
Elgh, Fredrik
Ohlson, Nina
Ottander, Ulrika
author_facet Idahl, Annika
Lundin, Eva
Jurstrand, Margaretha
Kumlin, Urban
Elgh, Fredrik
Ohlson, Nina
Ottander, Ulrika
author_sort Idahl, Annika
collection PubMed
description Objective. To assess associations of Chlamydia trachomatis and Mycoplasma genitalium antibodies with epithelial ovarian tumors. Methods. Plasma samples from 291 women, undergoing surgery due to suspected ovarian pathology, were analyzed with respect to C. trachomatis IgG and IgA, chlamydial Heat Shock Protein 60-1 (cHSP60-1) IgG and M. genitalium IgG antibodies. Women with borderline tumors (n = 12), ovarian carcinoma (n = 45), or other pelvic malignancies (n = 11) were matched to four healthy controls each. Results. Overall, there were no associations of antibodies with EOC. However, chlamydial HSP60-1 IgG antibodies were associated with type II ovarian cancer (P = .002) in women with plasma samples obtained >1 year prior to diagnosis (n = 7). M. genitalium IgG antibodies were associated with borderline ovarian tumors (P = .01). Conclusion. Chlamydial HSP60-1 IgG and M. genitalium IgG antibodies are in this study associated with epithelial ovarian tumors in some subsets, which support the hypothesis linking upper-genital tract infections and ovarian tumor development.
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spelling pubmed-31470072011-08-02 Chlamydia trachomatis and Mycoplasma genitalium Plasma Antibodies in Relation to Epithelial Ovarian Tumors Idahl, Annika Lundin, Eva Jurstrand, Margaretha Kumlin, Urban Elgh, Fredrik Ohlson, Nina Ottander, Ulrika Infect Dis Obstet Gynecol Clinical Study Objective. To assess associations of Chlamydia trachomatis and Mycoplasma genitalium antibodies with epithelial ovarian tumors. Methods. Plasma samples from 291 women, undergoing surgery due to suspected ovarian pathology, were analyzed with respect to C. trachomatis IgG and IgA, chlamydial Heat Shock Protein 60-1 (cHSP60-1) IgG and M. genitalium IgG antibodies. Women with borderline tumors (n = 12), ovarian carcinoma (n = 45), or other pelvic malignancies (n = 11) were matched to four healthy controls each. Results. Overall, there were no associations of antibodies with EOC. However, chlamydial HSP60-1 IgG antibodies were associated with type II ovarian cancer (P = .002) in women with plasma samples obtained >1 year prior to diagnosis (n = 7). M. genitalium IgG antibodies were associated with borderline ovarian tumors (P = .01). Conclusion. Chlamydial HSP60-1 IgG and M. genitalium IgG antibodies are in this study associated with epithelial ovarian tumors in some subsets, which support the hypothesis linking upper-genital tract infections and ovarian tumor development. Hindawi Publishing Corporation 2011 2011-07-28 /pmc/articles/PMC3147007/ /pubmed/21811380 http://dx.doi.org/10.1155/2011/824627 Text en Copyright © 2011 Annika Idahl et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Idahl, Annika
Lundin, Eva
Jurstrand, Margaretha
Kumlin, Urban
Elgh, Fredrik
Ohlson, Nina
Ottander, Ulrika
Chlamydia trachomatis and Mycoplasma genitalium Plasma Antibodies in Relation to Epithelial Ovarian Tumors
title Chlamydia trachomatis and Mycoplasma genitalium Plasma Antibodies in Relation to Epithelial Ovarian Tumors
title_full Chlamydia trachomatis and Mycoplasma genitalium Plasma Antibodies in Relation to Epithelial Ovarian Tumors
title_fullStr Chlamydia trachomatis and Mycoplasma genitalium Plasma Antibodies in Relation to Epithelial Ovarian Tumors
title_full_unstemmed Chlamydia trachomatis and Mycoplasma genitalium Plasma Antibodies in Relation to Epithelial Ovarian Tumors
title_short Chlamydia trachomatis and Mycoplasma genitalium Plasma Antibodies in Relation to Epithelial Ovarian Tumors
title_sort chlamydia trachomatis and mycoplasma genitalium plasma antibodies in relation to epithelial ovarian tumors
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3147007/
https://www.ncbi.nlm.nih.gov/pubmed/21811380
http://dx.doi.org/10.1155/2011/824627
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