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Electron paramagnetic resonance spectroscopy in radiation research: Current status and perspectives
Exposure to radiation leads to a number of health-related malfunctions. Ionizing radiation is more harmful than non-ionizing radiation, as it causes both direct and indirect effects. Irradiation with ionizing radiation results in free radical-induced oxidative stress. Free radical-mediated oxidative...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications Pvt Ltd
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3147108/ https://www.ncbi.nlm.nih.gov/pubmed/21814437 http://dx.doi.org/10.4103/0975-7406.67006 |
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author | Rana, Sudha Chawla, Raman Kumar, Raj Singh, Shefali Zheleva, Antoaneta Dimitrova, Yanka Gadjeva, Veselina Arora, Rajesh Sultana, Sarwat Sharma, Rakesh Kumar |
author_facet | Rana, Sudha Chawla, Raman Kumar, Raj Singh, Shefali Zheleva, Antoaneta Dimitrova, Yanka Gadjeva, Veselina Arora, Rajesh Sultana, Sarwat Sharma, Rakesh Kumar |
author_sort | Rana, Sudha |
collection | PubMed |
description | Exposure to radiation leads to a number of health-related malfunctions. Ionizing radiation is more harmful than non-ionizing radiation, as it causes both direct and indirect effects. Irradiation with ionizing radiation results in free radical-induced oxidative stress. Free radical-mediated oxidative stress has been implicated in a plethora of diseased states, including cancer, arthritis, aging, Parkinson's disease, and so on. Electron Paramagnetic Resonance (EPR) spectroscopy has various applications to measure free radicals, in radiation research. Free radicals disintegrate immediately in aqueous environment. Free radicals can be detected indirectly by the EPR spin trapping technique in which these forms stabilize the radical adduct and produce characteristic EPR spectra for specific radicals. Ionizing radiation-induced free radicals in calcified tissues, for example, teeth, bone, and fingernail, can be detected directly by EPR spectroscopy, due to their extended stability. Various applications of EPR in radiation research studies are discussed in this review. |
format | Online Article Text |
id | pubmed-3147108 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Medknow Publications Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-31471082011-08-03 Electron paramagnetic resonance spectroscopy in radiation research: Current status and perspectives Rana, Sudha Chawla, Raman Kumar, Raj Singh, Shefali Zheleva, Antoaneta Dimitrova, Yanka Gadjeva, Veselina Arora, Rajesh Sultana, Sarwat Sharma, Rakesh Kumar J Pharm Bioallied Sci Invited Review Exposure to radiation leads to a number of health-related malfunctions. Ionizing radiation is more harmful than non-ionizing radiation, as it causes both direct and indirect effects. Irradiation with ionizing radiation results in free radical-induced oxidative stress. Free radical-mediated oxidative stress has been implicated in a plethora of diseased states, including cancer, arthritis, aging, Parkinson's disease, and so on. Electron Paramagnetic Resonance (EPR) spectroscopy has various applications to measure free radicals, in radiation research. Free radicals disintegrate immediately in aqueous environment. Free radicals can be detected indirectly by the EPR spin trapping technique in which these forms stabilize the radical adduct and produce characteristic EPR spectra for specific radicals. Ionizing radiation-induced free radicals in calcified tissues, for example, teeth, bone, and fingernail, can be detected directly by EPR spectroscopy, due to their extended stability. Various applications of EPR in radiation research studies are discussed in this review. Medknow Publications Pvt Ltd 2010 /pmc/articles/PMC3147108/ /pubmed/21814437 http://dx.doi.org/10.4103/0975-7406.67006 Text en © Journal of Pharmacy and Bioallied Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Invited Review Rana, Sudha Chawla, Raman Kumar, Raj Singh, Shefali Zheleva, Antoaneta Dimitrova, Yanka Gadjeva, Veselina Arora, Rajesh Sultana, Sarwat Sharma, Rakesh Kumar Electron paramagnetic resonance spectroscopy in radiation research: Current status and perspectives |
title | Electron paramagnetic resonance spectroscopy in radiation research: Current status and perspectives |
title_full | Electron paramagnetic resonance spectroscopy in radiation research: Current status and perspectives |
title_fullStr | Electron paramagnetic resonance spectroscopy in radiation research: Current status and perspectives |
title_full_unstemmed | Electron paramagnetic resonance spectroscopy in radiation research: Current status and perspectives |
title_short | Electron paramagnetic resonance spectroscopy in radiation research: Current status and perspectives |
title_sort | electron paramagnetic resonance spectroscopy in radiation research: current status and perspectives |
topic | Invited Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3147108/ https://www.ncbi.nlm.nih.gov/pubmed/21814437 http://dx.doi.org/10.4103/0975-7406.67006 |
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