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Confirmation of TNIP1 and IL23A as susceptibility loci for psoriatic arthritis
OBJECTIVES: To investigate a shared genetic aetiology for skin involvement in psoriasis and psoriatic arthritis (PsA) by genotyping single-nucleotide polymorphisms (SNPs), reported to be associated in genome-wide association studies of psoriasis, in patients with PsA. METHODS: SNPs with reported evi...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Group
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3147229/ https://www.ncbi.nlm.nih.gov/pubmed/21623003 http://dx.doi.org/10.1136/ard.2011.150102 |
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author | Bowes, John Orozco, Gisela Flynn, Edward Ho, Pauline Brier, Rasha Marzo-Ortega, Helena Coates, Laura McManus, Ross Ryan, Anthony W Kane, David Korendowych, Eleanor McHugh, Neil FitzGerald, Oliver Packham, Jonathan Morgan, Ann W Bruce, Ian N Barton, Anne |
author_facet | Bowes, John Orozco, Gisela Flynn, Edward Ho, Pauline Brier, Rasha Marzo-Ortega, Helena Coates, Laura McManus, Ross Ryan, Anthony W Kane, David Korendowych, Eleanor McHugh, Neil FitzGerald, Oliver Packham, Jonathan Morgan, Ann W Bruce, Ian N Barton, Anne |
author_sort | Bowes, John |
collection | PubMed |
description | OBJECTIVES: To investigate a shared genetic aetiology for skin involvement in psoriasis and psoriatic arthritis (PsA) by genotyping single-nucleotide polymorphisms (SNPs), reported to be associated in genome-wide association studies of psoriasis, in patients with PsA. METHODS: SNPs with reported evidence for association with psoriasis were genotyped in a PsA case and control collection from the UK and Ireland. Genotype and allele frequencies were compared between PsA cases and controls using the Armitage test for trend. RESULTS: Seven SNPs mapping to the IL1RN, TNIP1, TNFAIP3, TSC1, IL23A, SMARCA4 and RNF114 genes were successfully genotyped. The IL23A and TNIP1 genes showed convincing evidence for association (rs2066808, p = 9.1×10(−7); rs17728338, p = 3.5×10(−5), respectively) whilst SNPs mapping to the TNFAIP3, TSC1 and RNF114 genes showed nominal evidence for association (rs610604, p = 0.03; rs1076160, p = 0.03; rs495337, p = 0.0025). No evidence for association with IL1RN or SMARCA4 was found but the power to detect association was low. CONCLUSIONS: SNPs mapping to previously reported psoriasis loci show evidence for association to PSA, thus supporting the hypothesis that the genetic aetiology of skin involvement is the same in both PsA and psoriasis. |
format | Online Article Text |
id | pubmed-3147229 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BMJ Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-31472292011-08-15 Confirmation of TNIP1 and IL23A as susceptibility loci for psoriatic arthritis Bowes, John Orozco, Gisela Flynn, Edward Ho, Pauline Brier, Rasha Marzo-Ortega, Helena Coates, Laura McManus, Ross Ryan, Anthony W Kane, David Korendowych, Eleanor McHugh, Neil FitzGerald, Oliver Packham, Jonathan Morgan, Ann W Bruce, Ian N Barton, Anne Ann Rheum Dis Clinical and Epidemiological Research OBJECTIVES: To investigate a shared genetic aetiology for skin involvement in psoriasis and psoriatic arthritis (PsA) by genotyping single-nucleotide polymorphisms (SNPs), reported to be associated in genome-wide association studies of psoriasis, in patients with PsA. METHODS: SNPs with reported evidence for association with psoriasis were genotyped in a PsA case and control collection from the UK and Ireland. Genotype and allele frequencies were compared between PsA cases and controls using the Armitage test for trend. RESULTS: Seven SNPs mapping to the IL1RN, TNIP1, TNFAIP3, TSC1, IL23A, SMARCA4 and RNF114 genes were successfully genotyped. The IL23A and TNIP1 genes showed convincing evidence for association (rs2066808, p = 9.1×10(−7); rs17728338, p = 3.5×10(−5), respectively) whilst SNPs mapping to the TNFAIP3, TSC1 and RNF114 genes showed nominal evidence for association (rs610604, p = 0.03; rs1076160, p = 0.03; rs495337, p = 0.0025). No evidence for association with IL1RN or SMARCA4 was found but the power to detect association was low. CONCLUSIONS: SNPs mapping to previously reported psoriasis loci show evidence for association to PSA, thus supporting the hypothesis that the genetic aetiology of skin involvement is the same in both PsA and psoriasis. BMJ Group 2011-05-29 /pmc/articles/PMC3147229/ /pubmed/21623003 http://dx.doi.org/10.1136/ard.2011.150102 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/2.0/ and http://creativecommons.org/licenses/by-nc/2.0/legalcode. |
spellingShingle | Clinical and Epidemiological Research Bowes, John Orozco, Gisela Flynn, Edward Ho, Pauline Brier, Rasha Marzo-Ortega, Helena Coates, Laura McManus, Ross Ryan, Anthony W Kane, David Korendowych, Eleanor McHugh, Neil FitzGerald, Oliver Packham, Jonathan Morgan, Ann W Bruce, Ian N Barton, Anne Confirmation of TNIP1 and IL23A as susceptibility loci for psoriatic arthritis |
title | Confirmation of TNIP1 and IL23A as susceptibility loci for psoriatic arthritis |
title_full | Confirmation of TNIP1 and IL23A as susceptibility loci for psoriatic arthritis |
title_fullStr | Confirmation of TNIP1 and IL23A as susceptibility loci for psoriatic arthritis |
title_full_unstemmed | Confirmation of TNIP1 and IL23A as susceptibility loci for psoriatic arthritis |
title_short | Confirmation of TNIP1 and IL23A as susceptibility loci for psoriatic arthritis |
title_sort | confirmation of tnip1 and il23a as susceptibility loci for psoriatic arthritis |
topic | Clinical and Epidemiological Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3147229/ https://www.ncbi.nlm.nih.gov/pubmed/21623003 http://dx.doi.org/10.1136/ard.2011.150102 |
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