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Epigenetics of Estrogen Receptor Signaling: Role in Hormonal Cancer Progression and Therapy
Estrogen receptor (ERα) signaling plays a key role in hormonal cancer progression. ERα is a ligand-dependent transcription factor that modulates gene transcription via recruitment to the target gene chromatin. Emerging evidence suggests that ERα signaling has the potential to contribute to epigeneti...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3147309/ https://www.ncbi.nlm.nih.gov/pubmed/21814622 http://dx.doi.org/10.3390/cancers3021691 |
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author | Mann, Monica Cortez, Valerie Vadlamudi, Ratna K. |
author_facet | Mann, Monica Cortez, Valerie Vadlamudi, Ratna K. |
author_sort | Mann, Monica |
collection | PubMed |
description | Estrogen receptor (ERα) signaling plays a key role in hormonal cancer progression. ERα is a ligand-dependent transcription factor that modulates gene transcription via recruitment to the target gene chromatin. Emerging evidence suggests that ERα signaling has the potential to contribute to epigenetic changes. Estrogen stimulation is shown to induce several histone modifications at the ERα target gene promoters including acetylation, phosphorylation and methylation via dynamic interactions with histone modifying enzymes. Deregulation of enzymes involved in the ERα -mediated epigenetic pathway could play a vital role in ERα driven neoplastic processes. Unlike genetic alterations, epigenetic changes are reversible, and hence offer novel therapeutic opportunities to reverse ERα driven epigenetic changes. In this review, we summarize current knowledge on mechanisms by which ERα signaling potentiates epigenetic changes in cancer cells via histone modifications. |
format | Online Article Text |
id | pubmed-3147309 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-31473092011-08-01 Epigenetics of Estrogen Receptor Signaling: Role in Hormonal Cancer Progression and Therapy Mann, Monica Cortez, Valerie Vadlamudi, Ratna K. Cancers (Basel) Review Estrogen receptor (ERα) signaling plays a key role in hormonal cancer progression. ERα is a ligand-dependent transcription factor that modulates gene transcription via recruitment to the target gene chromatin. Emerging evidence suggests that ERα signaling has the potential to contribute to epigenetic changes. Estrogen stimulation is shown to induce several histone modifications at the ERα target gene promoters including acetylation, phosphorylation and methylation via dynamic interactions with histone modifying enzymes. Deregulation of enzymes involved in the ERα -mediated epigenetic pathway could play a vital role in ERα driven neoplastic processes. Unlike genetic alterations, epigenetic changes are reversible, and hence offer novel therapeutic opportunities to reverse ERα driven epigenetic changes. In this review, we summarize current knowledge on mechanisms by which ERα signaling potentiates epigenetic changes in cancer cells via histone modifications. Molecular Diversity Preservation International (MDPI) 2011-03-29 /pmc/articles/PMC3147309/ /pubmed/21814622 http://dx.doi.org/10.3390/cancers3021691 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Mann, Monica Cortez, Valerie Vadlamudi, Ratna K. Epigenetics of Estrogen Receptor Signaling: Role in Hormonal Cancer Progression and Therapy |
title | Epigenetics of Estrogen Receptor Signaling: Role in Hormonal Cancer Progression and Therapy |
title_full | Epigenetics of Estrogen Receptor Signaling: Role in Hormonal Cancer Progression and Therapy |
title_fullStr | Epigenetics of Estrogen Receptor Signaling: Role in Hormonal Cancer Progression and Therapy |
title_full_unstemmed | Epigenetics of Estrogen Receptor Signaling: Role in Hormonal Cancer Progression and Therapy |
title_short | Epigenetics of Estrogen Receptor Signaling: Role in Hormonal Cancer Progression and Therapy |
title_sort | epigenetics of estrogen receptor signaling: role in hormonal cancer progression and therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3147309/ https://www.ncbi.nlm.nih.gov/pubmed/21814622 http://dx.doi.org/10.3390/cancers3021691 |
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