Mitochondrial Medicine and the Neurodegenerative Mitochondriopathies

Neurodegenerative diseases are a common late-life scourge for which disease-modifying treatments are sorely needed. Mitochondrial perturbation is commonly observed in these diseases, so pursuing treatment development strategies that target mitochondria or processes affected by mitochondria seems rea...

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Detalles Bibliográficos
Autor principal: Swerdlow, Russell H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148068/
https://www.ncbi.nlm.nih.gov/pubmed/21814473
http://dx.doi.org/10.3390/ph2030150
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author Swerdlow, Russell H.
author_facet Swerdlow, Russell H.
author_sort Swerdlow, Russell H.
collection PubMed
description Neurodegenerative diseases are a common late-life scourge for which disease-modifying treatments are sorely needed. Mitochondrial perturbation is commonly observed in these diseases, so pursuing treatment development strategies that target mitochondria or processes affected by mitochondria seems reasonable. This review discusses the rationale underlying past and current efforts to treat neurodegenerative diseases using mitochondrial medicine, and tries to predict how future efforts might proceed.
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spelling pubmed-31480682011-08-01 Mitochondrial Medicine and the Neurodegenerative Mitochondriopathies Swerdlow, Russell H. Pharmaceuticals (Basel) Review Neurodegenerative diseases are a common late-life scourge for which disease-modifying treatments are sorely needed. Mitochondrial perturbation is commonly observed in these diseases, so pursuing treatment development strategies that target mitochondria or processes affected by mitochondria seems reasonable. This review discusses the rationale underlying past and current efforts to treat neurodegenerative diseases using mitochondrial medicine, and tries to predict how future efforts might proceed. Molecular Diversity Preservation International 2009-12-03 /pmc/articles/PMC3148068/ /pubmed/21814473 http://dx.doi.org/10.3390/ph2030150 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Swerdlow, Russell H.
Mitochondrial Medicine and the Neurodegenerative Mitochondriopathies
title Mitochondrial Medicine and the Neurodegenerative Mitochondriopathies
title_full Mitochondrial Medicine and the Neurodegenerative Mitochondriopathies
title_fullStr Mitochondrial Medicine and the Neurodegenerative Mitochondriopathies
title_full_unstemmed Mitochondrial Medicine and the Neurodegenerative Mitochondriopathies
title_short Mitochondrial Medicine and the Neurodegenerative Mitochondriopathies
title_sort mitochondrial medicine and the neurodegenerative mitochondriopathies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148068/
https://www.ncbi.nlm.nih.gov/pubmed/21814473
http://dx.doi.org/10.3390/ph2030150
work_keys_str_mv AT swerdlowrussellh mitochondrialmedicineandtheneurodegenerativemitochondriopathies

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