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Structural Basis for Sequence Specific DNA Binding and Protein Dimerization of HOXA13

The homeobox gene (HOXA13) codes for a transcription factor protein that binds to AT-rich DNA sequences and controls expression of genes during embryonic morphogenesis. Here we present the NMR structure of HOXA13 homeodomain (A13DBD) bound to an 11-mer DNA duplex. A13DBD forms a dimer that binds to...

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Detalles Bibliográficos
Autores principales:	Zhang, Yonghong, Larsen, Christine A., Stadler, H. Scott, Ames, James B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148250/ https://www.ncbi.nlm.nih.gov/pubmed/21829694 http://dx.doi.org/10.1371/journal.pone.0023069

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