Cargando…

Structural Basis for Sequence Specific DNA Binding and Protein Dimerization of HOXA13

The homeobox gene (HOXA13) codes for a transcription factor protein that binds to AT-rich DNA sequences and controls expression of genes during embryonic morphogenesis. Here we present the NMR structure of HOXA13 homeodomain (A13DBD) bound to an 11-mer DNA duplex. A13DBD forms a dimer that binds to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Yonghong, Larsen, Christine A., Stadler, H. Scott, Ames, James B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148250/ https://www.ncbi.nlm.nih.gov/pubmed/21829694 http://dx.doi.org/10.1371/journal.pone.0023069

Ejemplares similares

Backbone chemical shift assignments of mouse HOXA13 DNA binding domain bound to duplex DNA
por: Zhang, Yonghong, et al.
Publicado: (2010)

(1)H, (15)N, and (13)C chemical shift assignments of mouse HOXA13 DNA binding domain
por: Zhang, Yonghong, et al.
Publicado: (2009)

HOXA13 Is Essential for Placental Vascular Patterning and Labyrinth Endothelial Specification
por: Shaut, Carley A. E., et al.
Publicado: (2008)

HOXA13 in etiology and oncogenic potential of Barrett’s esophagus
por: Janmaat, Vincent T., et al.
Publicado: (2021)

Structural basis for dimerization quality control
por: Mena, Elijah L., et al.
Publicado: (2020)

Genetic and phenotypic continuum of HOXA genes: A case with double HOXA9/HOXA13 mutations
por: Jaouadi, Hager, et al.
Publicado: (2023)

Molecular Characterization of HOXA2 and HOXA3 Binding Properties
por: Mallen, Joshua, et al.
Publicado: (2021)

A genomic approach to the identification and characterization of HOXA13 functional binding elements
por: McCabe, Colleen D., et al.
Publicado: (2005)

Structural basis of specific DNA binding by the transcription factor ZBTB24
por: Ren, Ren, et al.
Publicado: (2019)

Structural basis for the cooperative DNA recognition by Smad4 MH1 dimers
por: Baburajendran, Nithya, et al.
Publicado: (2011)

Structural basis for dimerization and RNA binding of avian infectious bronchitis virus nsp9
por: Hu, Tingting, et al.
Publicado: (2017)

Structural basis for p53 binding to its nucleosomal target DNA sequence
por: Nishimura, Masahiro, et al.
Publicado: (2022)

The structural basis for partitioning of the XRCC1/DNA ligase III-α BRCT-mediated dimer complexes
por: Cuneo, Matthew J., et al.
Publicado: (2011)

Structural basis of dimerization and dual W-box DNA recognition by rice WRKY domain
por: Cheng, Xiankun, et al.
Publicado: (2019)

Structural basis of dimerization and nucleic acid binding of human DBHS proteins NONO and PSPC1
por: Knott, Gavin J, et al.
Publicado: (2021)

Sequence-Specific DNA Binding by Noncovalent Peptide–Azocyclodextrin Dimer Complex as a Suitable Model for Conformational Fuzziness
por: Quirolo, Zulma B., et al.
Publicado: (2019)

Structural basis underlying CAC RNA recognition by the RRM domain of dimeric RNA-binding protein RBPMS
por: Teplova, Marianna, et al.
Publicado: (2015)

The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator
por: Jungmichel, Stephanie, et al.
Publicado: (2012)

Structure of the RAG1 nonamer-binding domain with DNA reveals a dimer that mediates DNA synapsis
por: Fang Yin, Fang, et al.
Publicado: (2009)

Combinatorial bZIP dimers display complex DNA-binding specificity landscapes
por: Rodríguez-Martínez, José A, et al.
Publicado: (2017)

HOXA7, HOXA9, and HOXA10 are differentially expressed in clival and sacral chordomas
por: Jäger, Daniela, et al.
Publicado: (2017)

HOXA13 serves as a biomarker to predict neoadjuvant therapy efficacy in advanced colorectal cancer patients: HOXA13 predicts neoadjuvant therapy efficacy of CRC
por: Liu, Shuanghui, et al.
Publicado: (2022)

DNA-binding landscape of IRF3, IRF5 and IRF7 dimers: implications for dimer-specific gene regulation
por: Andrilenas, Kellen K, et al.
Publicado: (2018)

Role of HOXA7 to HOXA13 and PBX1 genes in various forms of MRKH syndrome (congenital absence of uterus and vagina)
por: Burel, Agnès, et al.
Publicado: (2006)

The role of HoxA11 and HoxA13 in the evolution of novel fin morphologies in a representative batoid (Leucoraja erinacea)
por: Barry, Shannon N., et al.
Publicado: (2017)

Structural basis for specific DNA sequence motif recognition by the TFAP2 transcription factors
por: Liu, Ke, et al.
Publicado: (2023)

Structural basis for functional interactions in dimers of SLC26 transporters
por: Chang, Yung-Ning, et al.
Publicado: (2019)

Structure revision of cryptosporioptides and determination of the genetic basis for dimeric xanthone biosynthesis in fungi
por: Greco, Claudio, et al.
Publicado: (2019)

Dimerization of Neuronal Calcium Sensor Proteins
por: Ames, James B.
Publicado: (2018)

GDNF-inducible zinc finger protein 1 is a sequence-specific transcriptional repressor that binds to the HOXA10 gene regulatory region
por: Morinaga, Takatoshi, et al.
Publicado: (2005)

Structural Basis for Variant-Specific Neuroligin-Binding by α-Neurexin
por: Tanaka, Hiroki, et al.
Publicado: (2011)

The glucocorticoid receptor dimer interface allosterically transmits sequence-specific DNA signals
por: Watson, Lisa C., et al.
Publicado: (2013)

HOXA1 and TALE proteins display cross-regulatory interactions and form a combinatorial binding code on HOXA1 targets
por: De Kumar, Bony, et al.
Publicado: (2017)

HOXA13 and HOXD13 expression during development of the syndactylous digits in the marsupial Macropus eugenii
por: Chew, Keng Yih, et al.
Publicado: (2012)

Differential Protein Expression Patterns of HOXA13 and HOXB13 Are Associated with Bladder Cancer Progression
por: Chin, Fee-Wai, et al.
Publicado: (2023)

Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization
por: Haq, Tamanna, et al.
Publicado: (2015)

Structural basis for ligand-dependent dimerization of phenylalanine hydroxylase regulatory domain
por: Patel, Dipali, et al.
Publicado: (2016)

Structural Basis and Mechanism for Vindoline Dimers Interacting with α,β-Tubulin
por: Zhang, Zhengqiong, et al.
Publicado: (2019)

Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium
por: Gandhi, Amit K., et al.
Publicado: (2021)

Structural basis of dimerization of chemokine receptors CCR5 and CXCR4
por: Di Marino, Daniele, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_fn0kjsaf5dv9j350qe3i9hdnhu