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Metabolic effects of an entero-omentectomy in mildly obese type 2 diabetes mellitus patients after three years

BACKGROUND: Various digestive tract procedures effectively improve metabolic syndrome, especially the control of type 2 diabetes mellitus. Very good metabolic results have been shown with vertical gastrectomy and entero-omentectomy; however, the metabolic effects of an isolated entero-omentectomy ha...

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Autores principales: Milleo, Fábio Quirilo, Campos, Antonio Carlos Ligocki, Santoro, Sérgio, Lacombe, Arnaldo, Santo, Marco Aurélio, Vicari, Marcelo Ricardo, Nogaroto, Viviane, Artoni, Roberto Ferreira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148469/
https://www.ncbi.nlm.nih.gov/pubmed/21876979
http://dx.doi.org/10.1590/S1807-59322011000700018
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author Milleo, Fábio Quirilo
Campos, Antonio Carlos Ligocki
Santoro, Sérgio
Lacombe, Arnaldo
Santo, Marco Aurélio
Vicari, Marcelo Ricardo
Nogaroto, Viviane
Artoni, Roberto Ferreira
author_facet Milleo, Fábio Quirilo
Campos, Antonio Carlos Ligocki
Santoro, Sérgio
Lacombe, Arnaldo
Santo, Marco Aurélio
Vicari, Marcelo Ricardo
Nogaroto, Viviane
Artoni, Roberto Ferreira
author_sort Milleo, Fábio Quirilo
collection PubMed
description BACKGROUND: Various digestive tract procedures effectively improve metabolic syndrome, especially the control of type 2 diabetes mellitus. Very good metabolic results have been shown with vertical gastrectomy and entero-omentectomy; however, the metabolic effects of an isolated entero-omentectomy have not been previously studied. METHODS: : Nine patients with type 2 diabetes mellitus and a body mass index ranging from 29 to 34.8 kg/m(2) underwent an entero-omentectomy procedure that consisted of an enterectomy of the middle jejunum and exeresis of the major part of the omentum performed through a mini-laparotomy. Glucagon-like peptide-1 and peptide YY were measured preoperatively and three months following the operation. Fasting and postprandial variations in glycemia, insulinemia, triglyceridemia, hemoglobin A1c, and body mass index were determined in the preoperative period and 3, 18 and, 36 months after the operation. RESULTS: : All patients significantly improved the control of their type 2 diabetes mellitus. Postprandial secretion of peptide YY and Glucagon-like peptide-1 were enhanced, whereas hemoglobin A1c, fasting and postprandial glucose, insulin, and triglyceride levels were significantly reduced. Mean body mass index was reduced from 31.1 to 27.3 kg/m(2). No major surgical or nutritional complications occurred. CONCLUSIONS: : Entero-omentectomy is easy and safe to perform. A simple reduction in jejunal extension and visceral fat causes important improvements in the metabolic profile.
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spelling pubmed-31484692011-08-03 Metabolic effects of an entero-omentectomy in mildly obese type 2 diabetes mellitus patients after three years Milleo, Fábio Quirilo Campos, Antonio Carlos Ligocki Santoro, Sérgio Lacombe, Arnaldo Santo, Marco Aurélio Vicari, Marcelo Ricardo Nogaroto, Viviane Artoni, Roberto Ferreira Clinics (Sao Paulo) Clinical Science BACKGROUND: Various digestive tract procedures effectively improve metabolic syndrome, especially the control of type 2 diabetes mellitus. Very good metabolic results have been shown with vertical gastrectomy and entero-omentectomy; however, the metabolic effects of an isolated entero-omentectomy have not been previously studied. METHODS: : Nine patients with type 2 diabetes mellitus and a body mass index ranging from 29 to 34.8 kg/m(2) underwent an entero-omentectomy procedure that consisted of an enterectomy of the middle jejunum and exeresis of the major part of the omentum performed through a mini-laparotomy. Glucagon-like peptide-1 and peptide YY were measured preoperatively and three months following the operation. Fasting and postprandial variations in glycemia, insulinemia, triglyceridemia, hemoglobin A1c, and body mass index were determined in the preoperative period and 3, 18 and, 36 months after the operation. RESULTS: : All patients significantly improved the control of their type 2 diabetes mellitus. Postprandial secretion of peptide YY and Glucagon-like peptide-1 were enhanced, whereas hemoglobin A1c, fasting and postprandial glucose, insulin, and triglyceride levels were significantly reduced. Mean body mass index was reduced from 31.1 to 27.3 kg/m(2). No major surgical or nutritional complications occurred. CONCLUSIONS: : Entero-omentectomy is easy and safe to perform. A simple reduction in jejunal extension and visceral fat causes important improvements in the metabolic profile. Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2011-07 /pmc/articles/PMC3148469/ /pubmed/21876979 http://dx.doi.org/10.1590/S1807-59322011000700018 Text en Copyright © 2011 Hospital das Clínicas da FMUSP http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Science
Milleo, Fábio Quirilo
Campos, Antonio Carlos Ligocki
Santoro, Sérgio
Lacombe, Arnaldo
Santo, Marco Aurélio
Vicari, Marcelo Ricardo
Nogaroto, Viviane
Artoni, Roberto Ferreira
Metabolic effects of an entero-omentectomy in mildly obese type 2 diabetes mellitus patients after three years
title Metabolic effects of an entero-omentectomy in mildly obese type 2 diabetes mellitus patients after three years
title_full Metabolic effects of an entero-omentectomy in mildly obese type 2 diabetes mellitus patients after three years
title_fullStr Metabolic effects of an entero-omentectomy in mildly obese type 2 diabetes mellitus patients after three years
title_full_unstemmed Metabolic effects of an entero-omentectomy in mildly obese type 2 diabetes mellitus patients after three years
title_short Metabolic effects of an entero-omentectomy in mildly obese type 2 diabetes mellitus patients after three years
title_sort metabolic effects of an entero-omentectomy in mildly obese type 2 diabetes mellitus patients after three years
topic Clinical Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148469/
https://www.ncbi.nlm.nih.gov/pubmed/21876979
http://dx.doi.org/10.1590/S1807-59322011000700018
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