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Thermographic evaluation of hind paw skin temperature and functional recovery of locomotion after sciatic nerve crush in rats
INTRODUCTION: Peripheral nerves are often damaged by direct mechanical injury, diseases, and tumors. The peripheral nerve injuries that result from these conditions can lead to a partial or complete loss of motor, sensory, and autonomic functions, which in turn are related to changes in skin tempera...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148474/ https://www.ncbi.nlm.nih.gov/pubmed/21876984 http://dx.doi.org/10.1590/S1807-59322011000700023 |
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author | Z. Sacharuk, Viviane A. Lovatel, Gisele Ilha, Jocemar Marcuzzo, Simone Severo do Pinho, Alexandre L. Xavier, Léder A. Zaro, Milton Achaval, Matilde |
author_facet | Z. Sacharuk, Viviane A. Lovatel, Gisele Ilha, Jocemar Marcuzzo, Simone Severo do Pinho, Alexandre L. Xavier, Léder A. Zaro, Milton Achaval, Matilde |
author_sort | Z. Sacharuk, Viviane |
collection | PubMed |
description | INTRODUCTION: Peripheral nerves are often damaged by direct mechanical injury, diseases, and tumors. The peripheral nerve injuries that result from these conditions can lead to a partial or complete loss of motor, sensory, and autonomic functions, which in turn are related to changes in skin temperature, in the involved segments of the body. The aim of this study was to evaluate the changes in hind paw skin temperature after sciatic nerve crush in rats in an attempt to determine whether changes in skin temperature correlate with the functional recovery of locomotion. METHODS: Wistar rats were divided into three groups: control (n = 7), sham (n = 25), and crush (n = 25). All groups were subjected to thermographic, functional, and histological assessments. RESULTS: ΔT in the crush group was different from the control and sham groups at the 1(st), 3(rd) and 7(rd) postoperative days (p<0.05). The functional recovery from the crush group returned to normal values between the 3(rd) and 4(th) week post-injury, and morphological analysis of the nerve revealed incomplete regeneration at the 4(th) week after injury. DISCUSSION: This study is the first demonstration that sciatic nerve crush in rats induces an increase in hind paw skin temperature and that skin temperature changes do not correlate closely with functional recovery |
format | Online Article Text |
id | pubmed-3148474 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo |
record_format | MEDLINE/PubMed |
spelling | pubmed-31484742011-08-03 Thermographic evaluation of hind paw skin temperature and functional recovery of locomotion after sciatic nerve crush in rats Z. Sacharuk, Viviane A. Lovatel, Gisele Ilha, Jocemar Marcuzzo, Simone Severo do Pinho, Alexandre L. Xavier, Léder A. Zaro, Milton Achaval, Matilde Clinics (Sao Paulo) Basic Research INTRODUCTION: Peripheral nerves are often damaged by direct mechanical injury, diseases, and tumors. The peripheral nerve injuries that result from these conditions can lead to a partial or complete loss of motor, sensory, and autonomic functions, which in turn are related to changes in skin temperature, in the involved segments of the body. The aim of this study was to evaluate the changes in hind paw skin temperature after sciatic nerve crush in rats in an attempt to determine whether changes in skin temperature correlate with the functional recovery of locomotion. METHODS: Wistar rats were divided into three groups: control (n = 7), sham (n = 25), and crush (n = 25). All groups were subjected to thermographic, functional, and histological assessments. RESULTS: ΔT in the crush group was different from the control and sham groups at the 1(st), 3(rd) and 7(rd) postoperative days (p<0.05). The functional recovery from the crush group returned to normal values between the 3(rd) and 4(th) week post-injury, and morphological analysis of the nerve revealed incomplete regeneration at the 4(th) week after injury. DISCUSSION: This study is the first demonstration that sciatic nerve crush in rats induces an increase in hind paw skin temperature and that skin temperature changes do not correlate closely with functional recovery Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2011-07 /pmc/articles/PMC3148474/ /pubmed/21876984 http://dx.doi.org/10.1590/S1807-59322011000700023 Text en Copyright © 2011 Hospital das Clínicas da FMUSP http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Basic Research Z. Sacharuk, Viviane A. Lovatel, Gisele Ilha, Jocemar Marcuzzo, Simone Severo do Pinho, Alexandre L. Xavier, Léder A. Zaro, Milton Achaval, Matilde Thermographic evaluation of hind paw skin temperature and functional recovery of locomotion after sciatic nerve crush in rats |
title | Thermographic evaluation of hind paw skin temperature and functional recovery of locomotion after sciatic nerve crush in rats |
title_full | Thermographic evaluation of hind paw skin temperature and functional recovery of locomotion after sciatic nerve crush in rats |
title_fullStr | Thermographic evaluation of hind paw skin temperature and functional recovery of locomotion after sciatic nerve crush in rats |
title_full_unstemmed | Thermographic evaluation of hind paw skin temperature and functional recovery of locomotion after sciatic nerve crush in rats |
title_short | Thermographic evaluation of hind paw skin temperature and functional recovery of locomotion after sciatic nerve crush in rats |
title_sort | thermographic evaluation of hind paw skin temperature and functional recovery of locomotion after sciatic nerve crush in rats |
topic | Basic Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148474/ https://www.ncbi.nlm.nih.gov/pubmed/21876984 http://dx.doi.org/10.1590/S1807-59322011000700023 |
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