A New Hydroxylated Nonaprenylhydroquinone from the Mediterranean Marine Sponge Sarcotragus spinosulus

Chemical investigation of the Mediterranean sponge Sarcotragus spinosulus led to the isolation of a new hydroxylated nonaprenylhydroquinone, along with two known metabolites, hepta- and octaprenylhydroquinones. The structure of the new metabolite was assigned by extensive 1D and 2D NMR analyses and...

Descripción completa

Detalles Bibliográficos
Autores principales: Abed, Charline, Legrave, Nathalie, Dufies, Maeva, Robert, Guillaume, Guérineau, Vincent, Vacelet, Jean, Auberger, Patrick, Amade, Philippe, Mehiri, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148498/
https://www.ncbi.nlm.nih.gov/pubmed/21822411
http://dx.doi.org/10.3390/md9071210
_version_ 1782209348665081856
author Abed, Charline
Legrave, Nathalie
Dufies, Maeva
Robert, Guillaume
Guérineau, Vincent
Vacelet, Jean
Auberger, Patrick
Amade, Philippe
Mehiri, Mohamed
author_facet Abed, Charline
Legrave, Nathalie
Dufies, Maeva
Robert, Guillaume
Guérineau, Vincent
Vacelet, Jean
Auberger, Patrick
Amade, Philippe
Mehiri, Mohamed
author_sort Abed, Charline
collection PubMed
description Chemical investigation of the Mediterranean sponge Sarcotragus spinosulus led to the isolation of a new hydroxylated nonaprenylhydroquinone, along with two known metabolites, hepta- and octaprenylhydroquinones. The structure of the new metabolite was assigned by extensive 1D and 2D NMR analyses and MS studies. The antileukemic effect of the three compounds towards the chronic myelogenous leukemia (CML) cells line K562 was also evaluated.
format Online
Article
Text
id pubmed-3148498
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Molecular Diversity Preservation International
record_format MEDLINE/PubMed
spelling pubmed-31484982011-08-05 A New Hydroxylated Nonaprenylhydroquinone from the Mediterranean Marine Sponge Sarcotragus spinosulus Abed, Charline Legrave, Nathalie Dufies, Maeva Robert, Guillaume Guérineau, Vincent Vacelet, Jean Auberger, Patrick Amade, Philippe Mehiri, Mohamed Mar Drugs Article Chemical investigation of the Mediterranean sponge Sarcotragus spinosulus led to the isolation of a new hydroxylated nonaprenylhydroquinone, along with two known metabolites, hepta- and octaprenylhydroquinones. The structure of the new metabolite was assigned by extensive 1D and 2D NMR analyses and MS studies. The antileukemic effect of the three compounds towards the chronic myelogenous leukemia (CML) cells line K562 was also evaluated. Molecular Diversity Preservation International 2011-07-07 /pmc/articles/PMC3148498/ /pubmed/21822411 http://dx.doi.org/10.3390/md9071210 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Abed, Charline
Legrave, Nathalie
Dufies, Maeva
Robert, Guillaume
Guérineau, Vincent
Vacelet, Jean
Auberger, Patrick
Amade, Philippe
Mehiri, Mohamed
A New Hydroxylated Nonaprenylhydroquinone from the Mediterranean Marine Sponge Sarcotragus spinosulus
title A New Hydroxylated Nonaprenylhydroquinone from the Mediterranean Marine Sponge Sarcotragus spinosulus
title_full A New Hydroxylated Nonaprenylhydroquinone from the Mediterranean Marine Sponge Sarcotragus spinosulus
title_fullStr A New Hydroxylated Nonaprenylhydroquinone from the Mediterranean Marine Sponge Sarcotragus spinosulus
title_full_unstemmed A New Hydroxylated Nonaprenylhydroquinone from the Mediterranean Marine Sponge Sarcotragus spinosulus
title_short A New Hydroxylated Nonaprenylhydroquinone from the Mediterranean Marine Sponge Sarcotragus spinosulus
title_sort new hydroxylated nonaprenylhydroquinone from the mediterranean marine sponge sarcotragus spinosulus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148498/
https://www.ncbi.nlm.nih.gov/pubmed/21822411
http://dx.doi.org/10.3390/md9071210
work_keys_str_mv AT abedcharline anewhydroxylatednonaprenylhydroquinonefromthemediterraneanmarinespongesarcotragusspinosulus
AT legravenathalie anewhydroxylatednonaprenylhydroquinonefromthemediterraneanmarinespongesarcotragusspinosulus
AT dufiesmaeva anewhydroxylatednonaprenylhydroquinonefromthemediterraneanmarinespongesarcotragusspinosulus
AT robertguillaume anewhydroxylatednonaprenylhydroquinonefromthemediterraneanmarinespongesarcotragusspinosulus
AT guerineauvincent anewhydroxylatednonaprenylhydroquinonefromthemediterraneanmarinespongesarcotragusspinosulus
AT vaceletjean anewhydroxylatednonaprenylhydroquinonefromthemediterraneanmarinespongesarcotragusspinosulus
AT aubergerpatrick anewhydroxylatednonaprenylhydroquinonefromthemediterraneanmarinespongesarcotragusspinosulus
AT amadephilippe anewhydroxylatednonaprenylhydroquinonefromthemediterraneanmarinespongesarcotragusspinosulus
AT mehirimohamed anewhydroxylatednonaprenylhydroquinonefromthemediterraneanmarinespongesarcotragusspinosulus
AT abedcharline newhydroxylatednonaprenylhydroquinonefromthemediterraneanmarinespongesarcotragusspinosulus
AT legravenathalie newhydroxylatednonaprenylhydroquinonefromthemediterraneanmarinespongesarcotragusspinosulus
AT dufiesmaeva newhydroxylatednonaprenylhydroquinonefromthemediterraneanmarinespongesarcotragusspinosulus
AT robertguillaume newhydroxylatednonaprenylhydroquinonefromthemediterraneanmarinespongesarcotragusspinosulus
AT guerineauvincent newhydroxylatednonaprenylhydroquinonefromthemediterraneanmarinespongesarcotragusspinosulus
AT vaceletjean newhydroxylatednonaprenylhydroquinonefromthemediterraneanmarinespongesarcotragusspinosulus
AT aubergerpatrick newhydroxylatednonaprenylhydroquinonefromthemediterraneanmarinespongesarcotragusspinosulus
AT amadephilippe newhydroxylatednonaprenylhydroquinonefromthemediterraneanmarinespongesarcotragusspinosulus
AT mehirimohamed newhydroxylatednonaprenylhydroquinonefromthemediterraneanmarinespongesarcotragusspinosulus

Ejemplares similares