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Elevated transforming growth factor β and mitogen-activated protein kinase pathways mediate fibrotic traits of Dupuytren's disease fibroblasts

BACKGROUND: Dupuytren's disease is a fibroproliferative disorder of the palmar fascia. The treatment used to date has mostly been surgery, but there is a high recurrence rate. Transforming growth factor β (TGF-β) has been implicated as a key stimulator of myofibroblast activity and fascial cont...

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Detalles Bibliográficos
Autores principales:	Krause, Carola, Kloen, Peter, ten Dijke, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148569/ https://www.ncbi.nlm.nih.gov/pubmed/21711521 http://dx.doi.org/10.1186/1755-1536-4-14

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