Contribution of Alanine-76 and Serine Phosphorylation in α-Synuclein Membrane Association and Aggregation in Yeasts

In Parkinson's disease (PD), misfolded and aggregated α-synuclein protein accumulates in degenerating midbrain dopaminergic neurons. The amino acid alanine-76 in α-synuclein and phosphorylation at serine-87 and serine-129 are thought to regulate its aggregation and toxicity. However, their exac...

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Detalles Bibliográficos
Autores principales: Fiske, Michael, Valtierra, Stephanie, Solvang, Keith, Zorniak, Michael, White, Michael, Herrera, Sara, Konnikova, Alina, Brezinsky, Rebecca, DebBurman, Shubhik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148600/
https://www.ncbi.nlm.nih.gov/pubmed/21826257
http://dx.doi.org/10.4061/2011/392180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148600/
https://www.ncbi.nlm.nih.gov/pubmed/21826257
http://dx.doi.org/10.4061/2011/392180

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