SIV antigen immunization induces transient antigen-specific T cell responses and selectively activates viral replication in draining lymph nodes in retroviral suppressed rhesus macaques

BACKGROUND: HIV infection causes a qualitative and quantitative loss of CD4(+ )T cell immunity. The institution of anti-retroviral therapy (ART) restores CD4(+ )T cell responses to many pathogens, but HIV-specific responses remain deficient. Similarly, therapeutic immunization with HIV antigens of c...

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Detalles Bibliográficos
Autores principales: Hu, Haitao, Gama, Lucio, Aye, Pyone P, Clements, Janice E, Barry, Peter A, Lackner, Andrew A, Weissman, Drew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148979/
https://www.ncbi.nlm.nih.gov/pubmed/21752277
http://dx.doi.org/10.1186/1742-4690-8-57

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