Prevalence of Human African Trypanosomiasis in the Democratic Republic of the Congo

Human African Trypanosomiasis (HAT) is a major public health problem in the Democratic Republic of the Congo (DRC). Active and passive surveillance for HAT is conducted but may underestimate the true prevalence of the disease. We used ELISA to screen 7,769 leftover dried blood spots from a nationall...

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Autores principales: Mumba, Dieudonne, Bohorquez, Elaine, Messina, Jane, Kande, Victor, Taylor, Steven M., Tshefu, Antoinette K., Muwonga, Jeremie, Kashamuka, Melchior M., Emch, Michael, Tidwell, Richard, Büscher, Philippe, Meshnick, Steven R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149009/
https://www.ncbi.nlm.nih.gov/pubmed/21829736
http://dx.doi.org/10.1371/journal.pntd.0001246
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author Mumba, Dieudonne
Bohorquez, Elaine
Messina, Jane
Kande, Victor
Taylor, Steven M.
Tshefu, Antoinette K.
Muwonga, Jeremie
Kashamuka, Melchior M.
Emch, Michael
Tidwell, Richard
Büscher, Philippe
Meshnick, Steven R.
author_facet Mumba, Dieudonne
Bohorquez, Elaine
Messina, Jane
Kande, Victor
Taylor, Steven M.
Tshefu, Antoinette K.
Muwonga, Jeremie
Kashamuka, Melchior M.
Emch, Michael
Tidwell, Richard
Büscher, Philippe
Meshnick, Steven R.
author_sort Mumba, Dieudonne
collection PubMed
description Human African Trypanosomiasis (HAT) is a major public health problem in the Democratic Republic of the Congo (DRC). Active and passive surveillance for HAT is conducted but may underestimate the true prevalence of the disease. We used ELISA to screen 7,769 leftover dried blood spots from a nationally representative population-based survey, the 2007 Demographic and Health Survey. 26 samples were positive by ELISA. Three of these were also positive by trypanolysis and/or PCR. From these data, we estimate that there were 18,592 people with HAT (95% confidence interval, 4,883–32,302) in the DRC in 2007, slightly more than twice as many as were reported.
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spelling pubmed-31490092011-08-09 Prevalence of Human African Trypanosomiasis in the Democratic Republic of the Congo Mumba, Dieudonne Bohorquez, Elaine Messina, Jane Kande, Victor Taylor, Steven M. Tshefu, Antoinette K. Muwonga, Jeremie Kashamuka, Melchior M. Emch, Michael Tidwell, Richard Büscher, Philippe Meshnick, Steven R. PLoS Negl Trop Dis Research Article Human African Trypanosomiasis (HAT) is a major public health problem in the Democratic Republic of the Congo (DRC). Active and passive surveillance for HAT is conducted but may underestimate the true prevalence of the disease. We used ELISA to screen 7,769 leftover dried blood spots from a nationally representative population-based survey, the 2007 Demographic and Health Survey. 26 samples were positive by ELISA. Three of these were also positive by trypanolysis and/or PCR. From these data, we estimate that there were 18,592 people with HAT (95% confidence interval, 4,883–32,302) in the DRC in 2007, slightly more than twice as many as were reported. Public Library of Science 2011-08-02 /pmc/articles/PMC3149009/ /pubmed/21829736 http://dx.doi.org/10.1371/journal.pntd.0001246 Text en Mumba et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Mumba, Dieudonne
Bohorquez, Elaine
Messina, Jane
Kande, Victor
Taylor, Steven M.
Tshefu, Antoinette K.
Muwonga, Jeremie
Kashamuka, Melchior M.
Emch, Michael
Tidwell, Richard
Büscher, Philippe
Meshnick, Steven R.
Prevalence of Human African Trypanosomiasis in the Democratic Republic of the Congo
title Prevalence of Human African Trypanosomiasis in the Democratic Republic of the Congo
title_full Prevalence of Human African Trypanosomiasis in the Democratic Republic of the Congo
title_fullStr Prevalence of Human African Trypanosomiasis in the Democratic Republic of the Congo
title_full_unstemmed Prevalence of Human African Trypanosomiasis in the Democratic Republic of the Congo
title_short Prevalence of Human African Trypanosomiasis in the Democratic Republic of the Congo
title_sort prevalence of human african trypanosomiasis in the democratic republic of the congo
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149009/
https://www.ncbi.nlm.nih.gov/pubmed/21829736
http://dx.doi.org/10.1371/journal.pntd.0001246
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