Cargando…

Structural and functional basis for RNA cleavage by Ire1

BACKGROUND: The unfolded protein response (UPR) controls the protein folding capacity of the endoplasmic reticulum (ER). Central to this signaling pathway is the ER-resident bifunctional transmembrane kinase/endoribonuclease Ire1. The endoribonuclease (RNase) domain of Ire1 initiates a non-conventio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Korennykh, Alexei V, Korostelev, Andrei A, Egea, Pascal F, Finer-Moore, Janet, Stroud, Robert M, Zhang, Chao, Shokat, Kevan M, Walter, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149027/ https://www.ncbi.nlm.nih.gov/pubmed/21729333 http://dx.doi.org/10.1186/1741-7007-9-47

Ejemplares similares

Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1
por: Korennykh, Alexei V, et al.
Publicado: (2011)

Initiation of Translation in Bacteria by a Structured Eukaryotic IRES RNA
por: Colussi, Timothy M., et al.
Publicado: (2015)

Homeostatic adaptation to endoplasmic reticulum stress depends on Ire1 kinase activity
por: Rubio, Claudia, et al.
Publicado: (2011)

In vitro RNA Cleavage Assays to Characterize IRE1-dependent RNA Decay
por: Karagöz, G. Elif, et al.
Publicado: (2019)

Specificity in endoplasmic reticulum-stress signaling in yeast entails a step-wise engagement of HAC1 mRNA to clusters of the stress sensor Ire1
por: van Anken, Eelco, et al.
Publicado: (2014)

RNA structure probing reveals the structural basis of Dicer binding and cleavage
por: Luo, Qing-Jun, et al.
Publicado: (2021)

Structural basis for the binding of IRES RNAs to the head of the ribosomal 40S subunit
por: Muhs, Margarita, et al.
Publicado: (2011)

Structural basis of cohesin cleavage by separase
por: Lin, Zhonghui, et al.
Publicado: (2016)

Ensemble cryo-EM uncovers inchworm-like translocation of a viral IRES through the ribosome
por: Abeyrathne, Priyanka D, et al.
Publicado: (2016)

Structural basis for the biological relevance of the invariant apical stem in IRES-mediated translation
por: Fernández, Noemí, et al.
Publicado: (2011)

Structural basis for single-stranded RNA recognition and cleavage by C3PO
por: Zhang, Jing, et al.
Publicado: (2016)

The impact of RNA structure on picornavirus IRES activity
por: Martínez-Salas, Encarnación
Publicado: (2008)

The Structural Basis for mRNA Recognition and Cleavage by the Ribosome-Dependent Endonuclease RelE
por: Neubauer, Cajetan, et al.
Publicado: (2009)

Structures of SRP54 and SRP19, the Two Proteins that Organize the Ribonucleic Core of the Signal Recognition Particle from Pyrococcus furiosus
por: Egea, Pascal F., et al.
Publicado: (2008)

Structural basis for the recognition and cleavage of histone H3 by cathepsin L
por: Adams-Cioaba, Melanie A., et al.
Publicado: (2011)

Structural basis for the specificity of renin-mediated angiotensinogen cleavage
por: Carrell, Robin W., et al.
Publicado: (2019)

Structural basis for duplex RNA recognition and cleavage by Archaeoglobus fulgidus C3PO
por: Parizotto, Eneida A, et al.
Publicado: (2013)

Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic
por: Mendez, Aaron S, et al.
Publicado: (2015)

Crystal Structure of Human Nocturnin Catalytic Domain
por: Estrella, Michael A., et al.
Publicado: (2018)

The mechanism of pseudouridine synthases from a covalent complex with RNA, and alternate specificity for U2605 versus U2604 between close homologs
por: Czudnochowski, Nadine, et al.
Publicado: (2014)

Flipped Over U: Structural Basis for dsRNA Cleavage by the SARS-CoV-2 Endoribonuclease
por: Frazier, Meredith N., et al.
Publicado: (2022)

Electrostatic Interactions Guide the Active Site Face of a Structure-Specific Ribonuclease to Its RNA Substrate
por: Plantinga, Matthew J., et al.
Publicado: (2008)

Structural basis for sequence-dependent DNA cleavage by nonspecific endonucleases
por: Wang, Yi-Ting, et al.
Publicado: (2007)

Structural Basis of Cell Wall Cleavage by a Staphylococcal Autolysin
por: Zoll, Sebastian, et al.
Publicado: (2010)

Structural basis for ribosomal 16S rRNA cleavage by the cytotoxic domain of colicin E3
por: Ng, C Leong, et al.
Publicado: (2010)

Conformational inhibition of the HCV IRES RNA
por: Parsons, Jerod, et al.
Publicado: (2009)

Diversity in kinetics correlated with structure in nano body-stabilized LacY
por: Kumar, Hemant, et al.
Publicado: (2020)

Caspase-mediated cleavage of IRE1 controls apoptotic cell commitment during endoplasmic reticulum stress
por: Shemorry, Anna, et al.
Publicado: (2019)

Ire1-mediated decay in mammalian cells relies on mRNA sequence, structure, and translational status
por: Moore, Kristin, et al.
Publicado: (2015)

Structure of the Human Autophagy Initiating Kinase ULK1 in Complex with Potent Inhibitors
por: Lazarus, Michael B., et al.
Publicado: (2014)

LOOP IIId of the HCV IRES is essential for the structural rearrangement of the 40S-HCV IRES complex
por: Angulo, Jenniffer, et al.
Publicado: (2016)

Structural basis for +1 ribosomal frameshifting during EF-G-catalyzed translocation
por: Demo, Gabriel, et al.
Publicado: (2021)

A Quantitative Arabidopsis IRE1a Ribonuclease-Dependent in vitro mRNA Cleavage Assay for Functional Studies of Substrate Splicing and Decay Activities
por: Diwan, Danish, et al.
Publicado: (2021)

mRNA Targeting to ER Stress Signaling Sites
por: Aragón, Tomás, et al.
Publicado: (2008)

Rapid RNase L–driven arrest of protein synthesis in the dsRNA response without degradation of translation machinery
por: Donovan, Jesse, et al.
Publicado: (2017)

Structure and function of HCV IRES domains
por: Lukavsky, Peter J.
Publicado: (2009)

Quaternary structure analysis of IRE1
por: Bashir, Samirul, et al.
Publicado: (2023)

Structures of the Signal Recognition Particle Receptor from the Archaeon Pyrococcus furiosus: Implications for the Targeting Step at the Membrane
por: Egea, Pascal F., et al.
Publicado: (2008)

Viral IRES Prediction System - a Web Server for Prediction of the IRES Secondary Structure In Silico
por: Hong, Jun-Jie, et al.
Publicado: (2013)

Comparison between the HCV IRES domain IV RNA structure and the Iron Responsive Element
por: Tumban, Ebenezer, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_7sts7dssqighfp0pk82cie4pds