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Overexpression of HTRA1 Leads to Ultrastructural Changes in the Elastic Layer of Bruch's Membrane via Cleavage of Extracellular Matrix Components

Variants in the chromosomal region 10q26 are strongly associated with an increased risk for age-related macular degeneration (AMD). Two potential AMD genes are located in this region: ARMS2 and HTRA1 (high-temperature requirement A1). Previous studies have suggested that polymorphisms in the promoto...

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Detalles Bibliográficos
Autores principales:	Vierkotten, Sarah, Muether, Philipp S., Fauser, Sascha
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149070/ https://www.ncbi.nlm.nih.gov/pubmed/21829675 http://dx.doi.org/10.1371/journal.pone.0022959

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