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Attenuated Age-Related Thinning of Peripapillary Retinal Nerve Fiber Layer in Long Eyes
PURPOSE: To assess the impact of axial length on the age-related peripapillary retinal nerve fiber layer (RNFL) thinning. METHODS: This cross-sectional observational comparative case series included 172 eyes from 172 healthy Korean subjects. Peripapillary RNFL thickness was measured using an Optic D...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Ophthalmological Society
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149135/ https://www.ncbi.nlm.nih.gov/pubmed/21860571 http://dx.doi.org/10.3341/kjo.2011.25.4.248 |
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author | Kim, Eun-Ji Hong, Samin Kim, Chan Yun Lee, Eun Suk Seong, Gong Je |
author_facet | Kim, Eun-Ji Hong, Samin Kim, Chan Yun Lee, Eun Suk Seong, Gong Je |
author_sort | Kim, Eun-Ji |
collection | PubMed |
description | PURPOSE: To assess the impact of axial length on the age-related peripapillary retinal nerve fiber layer (RNFL) thinning. METHODS: This cross-sectional observational comparative case series included 172 eyes from 172 healthy Korean subjects. Peripapillary RNFL thickness was measured using an Optic Disc Cube 200 × 200 scan of spectral domain Cirrus HD OCT and the axial length was measured using IOL Master Advanced Technology. In age groups based on decade, the normal ranges of peripapillary RNFL thickness for average, quadrant, and clock-hour sectors were determined with 95% confidence intervals. After dividing the eyes into two groups according to axial length (cut-off, 24.50 mm), the degrees of age-related RNFL thinning were compared. RESULTS: Among the eyes included in the study, 53 (30.81%) were considered to be long eyes (axial length, 25.04 ± 0.48 µm) and 119 (69.19%) were short-to-normal length eyes (axial length, 23.57 ± 0.60 µm). The decrease in average RNFL thickness with age was less in long eyes (negative slope, -0.12 µm/yr) than in short-to-normal length eyes (negative slope, -0.32 µm/yr) (p < 0.001). CONCLUSIONS: Age-related thinning of peripapillary RNFL thickness is attenuated in long eyes compared to short-to-normal length eyes. |
format | Online Article Text |
id | pubmed-3149135 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | The Korean Ophthalmological Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-31491352011-08-22 Attenuated Age-Related Thinning of Peripapillary Retinal Nerve Fiber Layer in Long Eyes Kim, Eun-Ji Hong, Samin Kim, Chan Yun Lee, Eun Suk Seong, Gong Je Korean J Ophthalmol Original Article PURPOSE: To assess the impact of axial length on the age-related peripapillary retinal nerve fiber layer (RNFL) thinning. METHODS: This cross-sectional observational comparative case series included 172 eyes from 172 healthy Korean subjects. Peripapillary RNFL thickness was measured using an Optic Disc Cube 200 × 200 scan of spectral domain Cirrus HD OCT and the axial length was measured using IOL Master Advanced Technology. In age groups based on decade, the normal ranges of peripapillary RNFL thickness for average, quadrant, and clock-hour sectors were determined with 95% confidence intervals. After dividing the eyes into two groups according to axial length (cut-off, 24.50 mm), the degrees of age-related RNFL thinning were compared. RESULTS: Among the eyes included in the study, 53 (30.81%) were considered to be long eyes (axial length, 25.04 ± 0.48 µm) and 119 (69.19%) were short-to-normal length eyes (axial length, 23.57 ± 0.60 µm). The decrease in average RNFL thickness with age was less in long eyes (negative slope, -0.12 µm/yr) than in short-to-normal length eyes (negative slope, -0.32 µm/yr) (p < 0.001). CONCLUSIONS: Age-related thinning of peripapillary RNFL thickness is attenuated in long eyes compared to short-to-normal length eyes. The Korean Ophthalmological Society 2011-08 2011-07-22 /pmc/articles/PMC3149135/ /pubmed/21860571 http://dx.doi.org/10.3341/kjo.2011.25.4.248 Text en © 2011 The Korean Ophthalmological Society http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kim, Eun-Ji Hong, Samin Kim, Chan Yun Lee, Eun Suk Seong, Gong Je Attenuated Age-Related Thinning of Peripapillary Retinal Nerve Fiber Layer in Long Eyes |
title | Attenuated Age-Related Thinning of Peripapillary Retinal Nerve Fiber Layer in Long Eyes |
title_full | Attenuated Age-Related Thinning of Peripapillary Retinal Nerve Fiber Layer in Long Eyes |
title_fullStr | Attenuated Age-Related Thinning of Peripapillary Retinal Nerve Fiber Layer in Long Eyes |
title_full_unstemmed | Attenuated Age-Related Thinning of Peripapillary Retinal Nerve Fiber Layer in Long Eyes |
title_short | Attenuated Age-Related Thinning of Peripapillary Retinal Nerve Fiber Layer in Long Eyes |
title_sort | attenuated age-related thinning of peripapillary retinal nerve fiber layer in long eyes |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149135/ https://www.ncbi.nlm.nih.gov/pubmed/21860571 http://dx.doi.org/10.3341/kjo.2011.25.4.248 |
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