Genomic loss of the putative tumor suppressor gene E2A in human lymphoma

The transcription factor E2A is essential for lymphocyte development. In this study, we describe a recurrent E2A gene deletion in at least 70% of patients with Sézary syndrome (SS), a subtype of T cell lymphoma. Loss of E2A results in enhanced proliferation and cell cycle progression via derepressio...

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Detalles Bibliográficos
Autores principales: Steininger, Anne, Möbs, Markus, Ullmann, Reinhard, Köchert, Karl, Kreher, Stephan, Lamprecht, Björn, Anagnostopoulos, Ioannis, Hummel, Michael, Richter, Julia, Beyer, Marc, Janz, Martin, Klemke, Claus-Detlev, Stein, Harald, Dörken, Bernd, Sterry, Wolfram, Schrock, Evelin, Mathas, Stephan, Assaf, Chalid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149217/
https://www.ncbi.nlm.nih.gov/pubmed/21788410
http://dx.doi.org/10.1084/jem.20101785

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